Infectious Disease Flashcards
Examples of blood borne pathogens
Poliovirus
Hepatitis b virus
Trypanosomes
Examples of within the leukocytes
Herpesvirus
HIV
Mycobacteria
Spreads through red cells
Malaria
Enters the intestines but kills motor neurons
Poliovirus
An important mechanism for escape from antibody mediated host defenses
Antigenic variation
Theses has capability of resistance to antimicrobial peptide
Shigella
Staphylococcus aureus
Candida
This expresses protein A which binds to FC portion of the antibodies that inhibits phagocytosis
S aureus
Examples of injurious effects
Tuberculosis - type 4
HBV&HCV - immune response
Rheumatic Fever - cross reaction
Post strep GN- type 3
Factors for tissue tropism
Host cell receptor Cell lineage specific factor Anatomic barriers Local temp Ph Host defense
Mechanism of virus how they damage and kill cells
Direct cytopathic effects
Antiviral immune response
Transformation of infected cells
Characterized by increased vascular permeability and leukocytic infiltration and predominantly of neutrophils
Suppurative or purulent inflammation
Characterized by accumulation and aggregation of activated macrophages called epitheloid cells
Mononuclear and granulomatous inflammation
This is an exception to the host defense on skin
Larvae of schistosoma
Bacteria coordinately regulate gene expression within a large population process
Quorum sensing
Organisms live within a viscous layer of extracellular polysaccarchide that adhere to host tissue or devices
Biofilms
What bacteria adheres to host tissue using adhesin protein f and teichoic avid to fibronectin
Streptococcus pyogenes
Plays a role in septic shock, dic and adult respiratory distress syndrome
Endotoxins
Causes it to adhere to junction protein and is expressed on epithelial cells
Nectin 4
Pathognomonic of measels or rubeola
Koplik spot
Warthin finkeldey cells
Where does poliovirus infect cells by binding to this epithelial adhesion molecule
CD 155
Causes dengue fever and yellow fever
West nile virus
HSV infected cells contain large, pink to purple intranuclear inclusions
Cowdry type A
Causes chicken pox and shingles
Varicella zoster
Shingles causing facial paralysis
Ramsay Hunt Syndrome
Major determinant of whether a person clears the virus or becomes a chronic carrier
CTL
Chronic hepatitis B virus can lead to
Cirrhosis of the liver and increased hepatocellular carcinoma
What are seen in a PBS of px with EBV
Atypical lymphocyte
Downy cells
A focal suppurative inflammation of the skin and subcutaneous tissue
Furuncle
Boil
Example of category A
Anthrax
Botulism
Category C bioterrorism
Nipah virus
Hanta virus