WARNING: This is Tricky. Flashcards
True or False: Hepatitis C does NOT cause a carrier state.
TRUE! Hepatitis C causes chronic infection. No chronic states for HAV, HEV, and HCV.
Hemochromatosis is characterized by deposition of hemosiderin in many tissues. Skin pigmentation and polyarthritis in this condition is mostly due to ___.
NOT HEMOSIDERIN!
Pigmentation due to increased epidermal melanin production.
Polyarthritis due to Ca pyrophosphate (pseudogout)
True or False. Wilson’s disease is characterized by a decrease in ceruloplasmin, increase in hepatic copper content and increase in urinary excretion of copper.
True. :)
“The disease MOST likely to give rise to HCC is ____.”
Tyrosinemia!
Almost 40% will develop HCC despite adequate dietary control.
T/F. In CIN III, dysplasia has affected virtually all layers of the epithelium with marked koilocytic changes.
False! Koilocytotic changes and differentiation of surface cells have usually disappeared by CIN III (they are most prominent in CIN I).
T/F. HPV testing, if readily available, can be used as a screening tool for cervical Ca.
False! Most sexually active women will contract cervical HPV at some point in their lifetime limiting the usefulness of HPV testing as screening tool.
T/F. Adenomyosis refers to the growth of the endometrium down into the myometrium. With menses, they undergo cyclical bleeding producing menorrhagia, dysmenorrhea, and pelvic pain.
False! Ectopic tissue is derived from the stratum basalis and do NOT undergo cyclical bleeding (this occurs in endometriosis.)
Endometrial polyps usually appear: sessile/pedunculated?
Sessile (rarely pedunculated)
T/F. Inflammatory breast Ca is characterized by marked inflammatory infiltrates.
False! It only appears enlarged, swollen and erythematous due to infiltration of dermal lymphatics by tumor. True inflammation is minimal or absent.
T/F. Dementia is ALWAYS pathologic.
TRUE!
T/F. Nelson and Cushing syndromes are characterized by the presence of corticotroph cell adenomas and thus may present with signs of hypercortisolism.
False!
Remember that in Nelson syndrome, the adrenals were removed! Although you may have increased secretion of ACTH, the hormone cannot act on an absent adrenal to increase cortisol secretion.
On cut section, aldosterone-secreting adenomas resemble normal cells characteristic of which zone.
Zona fasciculata!
NOT zona glomerulosa (the layer normally producing aldosterone)
Increased testosterone causes oligospermia. T/F.
True.
In Duchenne’s muscular dystrophy, one expects enlargement of the calf muscles.
True!
This is pseudohypertrophy, caused initially by hypertrophy of muscle fibers followed by increase in fat and connective tissue as the muscle atrophies.
Hypokalemic periodic paralysis is characterized by mutations in channels selective for:
A. K
B. Na
C. Ca
D. Cl
B. Na!
