Skin

Question 1

This charactrizes all forms of acute eczematous dermaittis

Answer 1

Spongiosis

Question 2

This lesions show a central zone of dusky pink-gray discoloration that correlates with epidermal necrosis; surrounded by a pink-red rim, producing target-like lesions.

Answer 2

Erythema multiforme

Question 3

Infectious agents associated with erythema multiforme

Answer 3

Herpes simplex
Mycoplasma
Histoplasma capsulatum
Coccidioides immitis

Question 4

Drugs associated with erythema multiforme

Answer 4

Sulfonamide
Penicillin
Salicylate
Hydantoin
Antimalarials

Question 5

Plaques show marked epidermal hyperplasia with uniform downward extension of the rete ridges with prominent parakeratotic scale inflltrated by neutrophils

Answer 5

Psoriasis

Question 6

Pruritic, polygonal, planar, purple, papules and plaques

Answer 6

Lichen planus

Question 7

Dense, continuous infiltrate of lymphocytes along the dermoepidermal junction. Inflammation in the basal layer causes the interface to assume an angulated, zigzag contour (“sawtoothing.”)

Answer 7

Lichen planus,

the prototypic interface dermatitis

Question 8

Roughening of the skin due to local repetitive trauma, localized to nodules

Answer 8

Prurigo nodularis

Localized form of lichen simplex chronicus

Question 9

Deep skin infections caused by this fungus may reveal erythematous lesions that are nodular and show evidence of hemorrhage. This fungus is particularly angioinvasive.

Answer 9

Aspergillus

Question 10

Most common type of wart? Most common location?

Answer 10

Verruca vulgaris

Dorsal hand

Question 11

Common histologic denominator in all forms of pemphigus is:

Answer 11

Acanthyloysis

Question 12

Bullous Disorders Quiz

The different bullous disorders are characterized by acantholysis in different locations.

1. Subcorneal
2. Suprabasal
3. Subepidermal

Answer 12

1. Pemphigus folaceus
2. Pemphigus vulgaris
3. Dermatitis herpetiformis / bullous pemphigoid

Question 13

Bulloud pemphigoid occurring in a pregnant woman and resolving after childbrith.

Answer 13

Herpes gestationis

Question 14

In celiac disease and dermatitis herpetiformis, the patient produces these antibodies that attack gliadin.

Answer 14

IgA

Question 15

Seborrheic keratosis is characterized by activating mutations in:

Answer 15

FGF receptor 3

Question 16

Roughened, brown, waxy lesion that appear “stuck on” on the skin; common in elderly individuals.

Histology reveals sheets of smalls cells that resemble basal cells of the normal epidermis; associated with the presence of small keratin-filled cysts (horn cysts).

Answer 16

Seborrheic keratosis

Question 17

Common in sun-exposed areas, this lesion appears tan-brown with sandpaper-like consistency. Histology reveals cytologic atypia with hyperplasia of basal cells.

Is there an association with malignancy?
Treatment?
Characteristic mutation?

Answer 17

Actinic keratosis
May progress to full thickness atypia
(Squamous cell CA in situ)
Local cryotherapy or topical agents
p53

Question 18

Histologic features of actinic keratosis

Answer 18

SPAIN
Solar elastosis (dermis contains blue-gray elastic fibers due to sun damage)
Parakeratosis
Atypia
Inflammation (leukocytes in superficial dermis)
NOT full thickness (atypia)

Question 19

The MOST COMMON human cancer

Answer 19

Basal cell CA

Question 20

Basal cell CA is associated with dysregulation of the __ pathway

Answer 20

Sonic hedgehog (PTCH) pathway

Question 21

Pearly papules often containing prominent dilated subepidermal blood vessels

Answer 21

Basal cell Ca

Question 22

Most melanocytic nevi tend to show activating mutations in just one gene, usually:

Answer 22

BRAF, NRAS

Question 23

Biopsy of a skin lesion reveals cells with large nuclei with irregular contours having chromatin characteristically clumped at the periphery of the nuclear membrane and prominent eosinophilic nuclei. Cells grow as poorly formed cells ar all levels of the epidermis and as dermal balloon-like nodules.

Answer 23

Melanoma