IL-Q Flashcards
Th2 cytokines;Drive macrophages to produce increased amounts of MMPs
IL4
IL10
Constitutional symptoms multiple myeloma is probably due to elaboration of this interleukin which is a major mediator of the acute phase response.
IL-6
Attracts and activates eosinophils
IL-5
Secreted by RS cells; stimulates RS cells in an autocrine mechanism
IL13
Released by activated monocytes and increase expression of tissue factor on endothelial cells while decreasing thrombomodulin
IL1
Induction of proinflammatory proteins.Differentiation of Th17
IL1
Activation of basophils and eosinophils.Hematopoietic growth factor
IL3
Proliferation of effector T and B cells, NK cells
IL-2
Induction of TH2 differentiation.IgE class switch
IL4
This interleukin is secreted by macrophages and acts as a chemo attractant to neutrophils
IL8
Key interleukin in macrophage activation
IFN-Y
Released by activated macrophages and activates monocytes. Monocytes then differentiates into epithelioid histiocytes
TNF
Secreted by macrophages; acts on cd4 T cells and lead to generation of the TH1 subset capable of secreting IFN-Y
IL-12
H. pylori increases production of proinflammatory cytokines, in particular, ___, which recruits and activates neutrophils.
IL8
This cytokine promotes the production of IL17 by T cells. The receptor for this choline is mutated in which condition.
IL23
Inflammatory bowel disease
