Warfarin Flashcards
1
Q
MOA of warfarin
A
Vitamin K antagonist. Inhibitis synthesis of vitamin K dependant clotting factors F2,9,7,10
2
Q
Indications of Warfarin
A
AF Prosthetic valve PE, DVT Thromboembolic events incl stroke some MI
3
Q
Therapeutic range for AF, mechanical valve, DVT/Pe
A
AF: 3-5
Mechanical valve: 3-5
Dvt/pe: 2-4
5
Q
Safe therapeutic range of inr for dental procedures & minor surgery
A
INR 2-4
6
Q
Drugs that increases the effects of warfarin
A
Amiodarones Abx: Metronidazole Ciprofloxacillin Bactrims Antifungal Trimethoprim Azoles
Aspirin
NSAIDS
7
Q
Maintenance or monitoring of warfarin therapeutic effect
A
Weekly INR until reaches therapeutic range for 2 consecutive weeks.
Then start rv monthly
8
Q
Bridging therapy of warfarin
A
Warfarin effect takes 3-5days to completely see effect
Bridging with LMWH for 5 days
9
Q
Side effects of warfarin
A
Bleeding
Skin necrosis
Teratogenic
Purple toe
10
Q
Drugs that decrease effect of warfarin
A
Carbamazepine Phenytoin Phenobarbitol OCPs Vitamin K
11
Q
Other Anticoagulants
A
Direct FXa inhibitor - apixaban Direct thrombin(FII) inhibitor - dabigatran
