Warfarin Flashcards
1
Q
Warfarin: Prescribed for
A
DVT, pulmonary embolism, transient ischaemic attacks
2
Q
Warfarin: Examples
A
Warfarin is the most common anti-coagulant prescribed
3
Q
Warfarin: Mode of action
A
Antagonises the effects of vitamin K — a co-factor for the production of four clotting factors
4
Q
Warfarin: Contraindications
A
Haemophilia, cerebral thrombosis, peptic ulcers, hypertension, pregnancy
5
Q
Warfarin: Cautions
A
Surgery, Liver / Kidney impairment, breastfeeding
6
Q
Warfarin: Side effects
A
Haemorrhage is the worrying side effect!
7
Q
Warfarin: Interactions
A
Major changes in diet (salads / green vegetables) and alcohol consumption can affect anticoagulant control.
- Pomegranate juice increases the INR by inhibiting the CYP450 enzyme that metabolises warfarin.
- High doses of vitamin E inhibit platelet aggregation and should be avoided with warfarin
