W26-L2: Mitochondria Flashcards
1
Q
How many mitochondria are there in healthy cells?
A
200-10,000, around 1,000 in liver cells
2
Q
What are mitochondria?
A
Endosymbiotic bacteria
3
Q
What do mitochondria carry out?
A
Acetyl coA production from pyruvate or fatty acid oxidation, ketone body synthesis, TCA cycle and phosphorylation
4
Q
Why do mitochondria get damaged?
A
Electrons leak from electron transport chain to create ROS
5
Q
What is mitochondrial damage linked to?
A
Age related physiological degeneration
6
Q
What are mitochondrial diseases attributed to?
A
Mutations in mitochondrial and nuclear DNA
7
Q
What are ragged red fibres?
A
Hallmark of mitochondrial disease, red deposits in muscle
