W11 - Sedation/GA in Kids - Mistry Flashcards
4 Sedation techniques available for dental treatment
- Nitrous oxide
- GA
- Oral sedation
- IV sedation
- Combo
What is RA?
Relative analgesia
Ex. Nitrous oxide
- Partial analgesic affect
Features of NO (3)
- Conscious sedation
- Pt can breathe on their own
- Anxiolytic and analgesic
Features of Stage 1 Plane 1 - NO (6)
Moderate sedation and analgesia
- Increased pain threshold
- Normal vitals
- Reflexes unaffected
- Feeling relaxed and less scared
- Paraesthesia (tingling in fingers, lips)
- Can communicate and cooperate
Features of Stage 1 Plane 2 - NO (feeling, reflexes) (7)
Dissociation sedation and analgesia
- like plane 1 but further relaxation
- Reduced blink rate
- Pharyngeal reflex is reduced
- Laryngeal reflex intact
- “floating” euphoric sensation
- Can maintain open mouth
- Possibility of amnesia and time warp
How do stage 1 plane 1 and 2 differ from each other in terms of reflex?
Both planes will remain with laryngeal reflex
- Pharyngeal reflex is reduced in plane 2
What clinical tips can be done to help monitor pts dosage of Nitrous oxide?
No glasses - assess their eyes and blink rate
No bite block - ask if they can keep their mouth open (if not, has gone beyond plane 2)
Features of Stage 1: Plane 3 - NO
Total analgesia (not advised for dental practice)
No longer relative analgesia
- Pt may not be able to open mouth
- May be sleepy/sweaty/nauseous
- May not respond to words or pain
- Reduced pharyngeal and laryngeal reflexes
Features of stage 2 - NO (6)
Excitement or Delerium
- Not advised for dental surgery
- Excitement or struggling
- Pharyngeal and laryngeal reflexes significantly reduced
- Increased vitals (BP, HR, Resp)
- Dilated pupils
- Could have loss of consciousness
Features of stage 3 and stage 4 (NO)
Stage 3 - surgical anesthesia (GA)
Stage 4 - respiratory paralysis → death
Properties of N2O gas
- Non irritating
- Non flammable
- Colourless
- Sweet smelling
What makes N2O have quick onset and recovery (2)
Gas is relatively insoluble in blood
Primary saturation of blood and brain takes 3-5 min (induction)
How does the body metabolise N2O
It doesnt
- No biotransformation in body
- Excreted unchanged via the lungs (99%) at a similar rate to absorption
Effects of N2O on CNS (2)
- Acts directly on opioid receptors
- Acts of RAS - controls emotions
Produces:
- Analagesia
- Euphoria
- Amnesia
- Anxiolytic
Physiological effect of N2O on the CVS (3)
- No clinically significant difference to heart rate at therapeutic doses
- Reduced heart rate of first stage could be due to peripheral vasodilation or anxiolytic effect
- Peripheral vasodilation - flushing
Effects of N2O on resp
No direct effect
Non irritating
Caution with emphysema / COPD
Conditions to be mindful of with N2O
Emphysema
COPD
GIT (N2O can cause nausea)
Is N2O safe for pregnancy?
Yes generally
BUT
Passes readily through placenta
Avoid in first trimester (but not contraindicated)
Indications for N2O (3)
- Mild to mod anxiety (not severe)
- Sensitive to gag reflex
- Intolerance to long appointments
Contra-indications for N2O (7)
Airway blockage (cold, obstructive passage)
Precooperative child (<3 yo)
Uncooperative / severe behavioural problems
Intellectually disabled
Psychiatric disorders
Conditions with trapped gas
Significant medically compromised patients
What are some significant medically compromised scenarios where N2O is contraindicated?
Bleomycin chemotherapy - Lungs are fibrosed (contraindicated)
MTHFR Deficiency - metabolic disease assoc w/ hemocystinuria
Caution:
Complex cardiac conditions
Myasthenia gracis
MS
COPD
Severe asthma
What pts are at risk for N2O induced bone marrow suppression, neurotoxicity or increased homocysteine levels
- History of B12 or folate deficiency
- Vegetarians
- Pts on proton pump inhibitors or H2 blockers
- MTHFR deficiency
Not contraindicated (except MTHFR) - just take caution
Maximum percentage dose of N2O
50%
Though Mistry only goes up to 40%