W11 Drug Nutrient Interactions Flashcards
ACE inhibitors may have the following actions (select all that apply):
a. Chelate iron and inhibit its absorption
b. inhibit potassium excretion
c. increase urinary zinc excretion
d. increase re-uptake of serotonin
a, b, and c
*ACE inhibitors including benazepril HCL, captopril, enalapril, fosinopril, lisinopril, moexipril HCL, quinapril HCL, and ramipril - chelate iron and inhibit its absorption, inhibit potassium excretion, and increase urinary excretion.
Antacids containing magnesium ______ intestinal pH and ________ folate and riboflavin absorption.
a. increase, decrease
b. increase, increase
d. decrease, increase,
e. decrease, decrease
a. increase, decrease.
Mg containing antacids increase intestinal pH and decrease folate and riboflavin absorption.
The following class of drugs impairs the ability of microbes to ferment dietary fiber, produce vitamin K, and resorb water along the colon:
a. anthracyclines
b. antibiotics
c. antidepressants
d. antacids
b. antibiotics
Antidepressants can:
a. increase carb cravings
b. inhibit enzymatic actions
c. cause sensitivity to dietary tyramine.
d. a-c
d. a-c
* Tricyclic antidepressants - inhibit the actions of enzymes requiring CoQ10.
* monamine oxidase inhibitors (clorgiline, furazolidone, isocarboxazid, moclobemide, phenelzine, selegiline, tranylcypromine, toloxatone) - increase appetite and carbohydrate cravings, inhibit the actions of enzymes requiring B6, and cause sensitivity (with vasoconstriction, tachycardia, chest pains, headach, intracranial hemorrhage, cardiac arrthymias, cardiac failure) to dietary tyramine (found in cheese, smoked or pickled fish, chianti, banana peels, yeast, sausage, sauerkraut, beers, and ales).
antihypertensives ____
a. inhibit iron, folate, and vitamin B12 absorption.
b. inhibit actions of enzymes requiring CoQ10 and B6
c. chelate dietary calcium - preventing its absorption
d. a-c
d. a-c
* hydralazine & isoniazid - inhibit actions of enzymes requiring B6.
* beta-blockers (acebutolo, alprenolol, atenolol, esmolol, metoprolol, penbutolol, pindolol, propranolol) chelate dietary calcium preventing its absorption and inhibit the actions of enzymes requiring CoQ10.
* methyldopa - inhibits absorption of iron, folate, and vitamin B12, and inhibits the actions of enzymes requiring CoQ10.
True or false - anti-inflammatory drugs increase folate absorption?
False.
Anti-inflammatory (NSAIDs, aspirins, bromfenac, celecoxib, choline salicylate, diclofenac, diflunissal, etodolac, fenoprofen, flurbiprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, meclofenamate, mefenamic acid, nabumetone, naproxen, oxaprozin, piroxicam, rofecoxib, salisylic acid, sulfasalazine, sulindac) - INHIBIT folate absorption
Contraceptives containing estrogen inhibit absorption of:
a. vitamin A
b. folate
c. vitamin C
d. vitamin D
e. a-c
f. all of the above
e. a-c
Diuretics ____ urinary potassium excretion and _______ urinary excretion of thiamin, magnesium, and potassium:
a. inhibit, increase
b. inhibit, decrease
a. inhibit, increase.
Diuretics inhibit urinary potassium excretion and increase urinary excretion of thiamin, magnesium, and potassium
Glucocorticoids _______ calcium and folate absorption and _______ bone demineralization:
a. inhibit, improve
b. increase, decrease
c. inhibit, accelerate
c. inhibit, accelerate.
Glucocorticoids inhibit calcium and folate absorption and accelerate bone demineralization.
HMG-CoA reductase inhibitors inhibit the regulatory enzyme (HMG-CoA reductase) in the pathway of _____ synthesis:
a. vitamin A
b. vitamin D
c. biotin
d. CoQ10
d. CoQ10
* HMG-CoA reductase inhibitors (atorvastatin, cerivastatin, fluvastatin, lovastatin, pravastatin, simvastatin) inhibit the regulatory enzyme in the pathway of coenzyme Q10 synthesis.
hypocholesterolemics can:
a. bind bile acids, cholesterol, bile salts, and nutrients.
b. interfere with absorption of vitamin A, vitamin D, vitamin E, vitamin B12.
c. promote excretion of bile acids.
d. all of the above.
d. all of the above
* Hypocholesterolemics can bind bile acids, cholesterol, bile salts, and nutrients, decreasing the digestion and absorption of fatty acids, fat soluble vitamins, iron, vitamin B12, and beta-carotene (cholestyramine). They can interfere with absorption of vitamin A, D, E, and B12 (clofibrate), and bind and promote excretion of bile acids decreasing the absorption of fatty acids and fat soluble vitamins (colestipol).
hypoglycemics (especially metformin and phenformin) induce malabsorption of ____.
a. vitamin B6
b. vitamin B12
c. vitamin C
d. calcium
b. vitamin B12
* 6-30% https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867725/#:~:text=It%20has%20been%20reported%20that,deficiency%20due%20to%20metformin%20use.&text=In%20addition%2C%20some%20studies%20have,and%20dose%20of%20metformin%20use.
* ADA reccs regular monitoring of B12 when on metformin.
PPI’s inhibit absorption of (select 3) :
a. vitamin B12
b. iron
c. zinc
d. copper
a-c. Vitamin B12, iron, and zinc
True or false? Anthracyclines (cancer drugs) inhibit endogenous synthesis of coenzyme Q10.
True!
*These include daunorubicin, doxorubicin, epirubicin, idarubicin, and valrubicin.
Heparin (anticoagulant) interferes with activation of _____ and with _____ function.
a. vitamin C, osteoclast
b. vitamin C, osteoblast
c. vitamin D, osteoblast
c. vitamin D, osteoblast (new bone formation)
