Vulva Disorders

Question 1

What cell type lines the vulva?

Answer 1

Keratinizing squamous epithelium

Question 2

What lymph nodes do vuvlar neoplasms invade?

Answer 2

Inguinal lymph nodes

Question 3

Both HSV and molluscum contagiosum present with skin lesions and eosinophilic inclusions on histology. How can clinical presentation help distinguish between the two STIs?

Answer 3

HSV lesions are painful
HSV has intranuclear inclusions
Molluscum contagiosum inclusions are very large and cytoplasmic

Question 4

Is molluscum contagiosum in a child a trigger to consider child abuse?

Answer 4

No

Question 5

Koilocytes are pathognomonic for what infection?

Answer 5

HPV

Question 6

What does parakaratosis mean?

Answer 6

Retention of nuclei in the stratum corneum

Question 7

What is the difference between VIN and CIN?

Answer 7

Vulvar intraepithelial neoplasia
Cervical intraepithelial neoplasia
Both due to HPV (16/18)

Question 8

What is the difference between SCC and carcinoma in situ (intraepithelial neoplasia)?

Answer 8

SCC has invaded through the basement membrane

CIS has not invaded through the basement membrane

Question 9

Lichen sclerosus is a precursor for what lesion?

Answer 9

Well differentiated SCC (keratin pearls are present)

Question 10

What population is Lichen sclerosus typically found in?

Answer 10

Elderly women

Question 11

Describe the dermatologic findings of lichen sclerosus.

Answer 11

Parchment paper epithelium

Cracks and bleeds very easily

Question 12

A young girl presents with a clear, grape-like, polypoid mass emerging from her vagina. What cancer is the likely diagnosis?

Answer 12

Rhabdomyosarcoma

Question 13

DES was previously given for pregnancy associated nausea. Daughters of women who received DES have a higher rate of what cancer?

Answer 13

Clear cell carcinoma