Pharmacology During Pregnancy Flashcards
Why are NSAIDs generally contraindicated in late stage pregnancy?
Prostaglandins play a critical role in initiation of labor- contract uterine SM, promote formation of gap junctions
What is cervical dilation dependent upon?
Prostaglandins
What stimulates uterine contractions?
Prostaglandins
Oxytocin
What receptors modulate uterine relaxation?
β2
What does HELLP syndrome stand for?
Hemolysis
Elevated liver enzymes
Low platelets
What gel contains prostaglandin E2 and promotes cervical effacement when applied vaginally?
Dinoprostone
Oxytocin has no effect on cervical dilation, what is its use?
Labor induction after cervical ripening
Post partum hemorrhage
What agents can be given if oxytocin is ineffective at treating postpartum hemorrhage?
Ergonovine
Methylergonovine
What drug is most commonly used to inhibit labor?
Nifedipine
What β2 agonist can be used to inhibit labor? How long can this medication be used?
Terbutaline
48-72 hours (potential for serious maternal heart problems/death)
What is the safest NSAID to use during pregnancy?
Acetaminophen
How can you medically treat an abortion?
Mifepristone- progesterone antagonist
Misoprostol- prostaglandin E1 analog
What is generally considered the first line therapy for organic impotence?
Phosphodiesterase inhibitors
List 3 PDEIs.
Sildenafil
Vardenafil
Tadalafil
What is the MOA of PDEIs?
Block cGMP breakdown
Enhance vascular relaxation
Increase blood flow
