Reproductive Disorders Flashcards
What does hypogonadotropic hypogonadism refer to?
Low FH, LSH and impotence
What congenital condition leads to low GnRH hypogonadotropic hypogonadism?
Kallman’s syndrome
What are some acquired causes of deficits in GnRH?
Severe illness Surgery Stress OSA Narcotics Glucocorticoids
A deficiency in LH and FSH and be seen in infiltrative disease. What disease leads to iron deposits selectively in gonadotropes?
Hemachromatosis
What is the most common pituitary tumor?
Prolactinoma
What laboratory results are consistent with hypergonadotropic hypogonadism?
High FSH/LH, impotence
Laboratory evaluation of a male with Klinefelter’s syndrome often revels what findings for FSH, LH, and testosterone?
Elevated FSH/LH
Low T
(especially FSH due to lack of Sertoli cells)
What will laboratory evaluation (LH, FSH , T, E2) of a patient with androgen receptor mutations show?
High LH, FSH , T, E2
What are significant risks for a patient on T therapy?
BPH
Polycythemia
Elevation of LDL
Why are women more prone to disorders of the GnRH secretory program caused by stress, exercise, or nutrition?
GnRH secretion is very dynamic
What are the LH and FSH levels early in the follicular phase?
Equal
To evaluate a woman with disturbance in her menstrual cycle, what must be done?
Pregnancy test
Acquired hypergonadotropic hypogonadism in a woman due to premature ovarian insufficiency should cause you to look for signs of what other disorders?
Autoimmune disease
What other diseases is a woman with PCOS at risk for?
Endometrial cancer
DM
How can a woman with a tumor that causes hirsutism be differentiated from a woman with PCOS?
Tumors have rapid onset/severe symptoms
PCOS is a gradual process
