VOP-BLOOD TYPING Flashcards
What are proteins on the surface that stimulate immune response with antibodies that cause cell to clump?
•Agglutinogens
What are antibodies to blood surface protein absent in the host body?
•Agglutinins- from exposure, meat, playground.
If I am AO pos, I would have been exposed to what agglutinin/AB?
B agglutinin in my plasma from exposure
Do we have only one agglutinogen on surface of RBC?
NO- numerous antigens on RBC
Which are most like to cause a transfusion reaction?
OAB and RH
What are the MC common blood types?
O and A+ Type determined by alleles from parents
Which type is recessive?
O is recessive. AB are codominant
What indicates having the Rh factor?
(+) means RH
Which blood type has no agglutinin?
AB. Surface A B agglutinogens- RECIPIENT, no transfusion rxn
Which Blood type had A and B agglutinin?
Type O- no agglutinogens- DONOR
What occurs when RBC exposed to antibodies on surface of RBC?
Agglutination-clumping of cells. Important to not have Type B blood given to Type A b/c Type B antibody a would merge with Type Blood A surface protein. clump and lysis
Why does it take large exposure to mount hemolysis with RH type agglutinin?
slower formation than OAB. RH- 6 proteins Cc,Dd,Ee
What RH protein confers positive or negative?
D most prevalent and antigenic. Rh +means D subtype. Rh- means C or E subtype
Why is it not necessary to treat pregnant with Rh for the 1st time?
Senistiaxion occurs with repeated exposure. 1st exposure to Rh+ w/ Rh- mount mild immune response. Treat if mount response to Rh- fetus
What is agglutination and phagocyte of fetus RBCs in baby Rh+ and Rh- mother via Rh- ABY diffusing to placenta?
Erythroblastosis fetalis
