Viruses - RNA pos sense

Question 1

Picornavirus virus morphology

Answer 1

Naked RNA positive sense

Question 2

Transmission of picornavirus

Answer 2

Fecal oral route

Question 3

Proliferation of Positive sense virus

Answer 3

Viral RNA inserted in cell and host cell translate protein using own cell’s system

Question 4

Picornavirus protein product

Answer 4

Polyprotein cleaved by viral proteiases

Question 5

RNA positive sense replication occurs in what dcell part

Answer 5

Cytoplasm

Question 6

Examples of Picornavirus

Answer 6

Hepatitis A
Enterovirus (poliovirus, echovirus, coxsackie virs)
Rhinovirus

Question 7

Transmission of Polio and Replication

Answer 7

Fecal oral route, replicates in Peyer’s patches (2-3 weeks), then invasdes anterior horn of spinal cord

Question 8

Symptoms of polio

Answer 8

Asymmetric paralysis, myalgia, respiratory insufficiency from paralysis

Aseptic meningitis

Question 9

Treatment of Polio

Answer 9

NONE - only vaccine

Question 10

OPV vs IPV

Answer 10

OPV - live attenuated, creates both IgG and IgA
IPV - killed
bypasses GI tract, forms IgG not IgA

Question 11

Coxsackie A vs B

Answer 11

A - Hand, foot, and Mouth Disease - red vesicular rash
Viral meningitis
Summer months

B - dilated cardiomyopathy, Devil’s grip, Bornholm disease, pleurodynia - sharp pain on chest

Question 12

Unique features of rhinovirus compared to others picornavirus

Answer 12

Acid labnile. Cannot be transmitted fecal oral route

Question 13

Transmission of rhinovirus

Answer 13

Respiratory, attaches to ICAM-1 on host cells

Question 14

Rhinovirus grows in what temperatures

Answer 14

Cool temperatures, which is why ionfects upper respiratory tract

Question 15

Transmission of Hepatitis A

Answer 15

Fecal oral route, transmitted from infected feces contaminating water, shellfish

Question 16

Purifying techniques to avoid Hep A

Answer 16

Chlorinated,Bleached, UV radiation, bboiled

Question 17

Anicteric hepatitis in young children is caused by?

Answer 17

Hepatitis A

Question 18

Duration of illness in Hepatitis A

Answer 18

1 month self limiting, no carrier or chronic state

Question 19

Hepatitis A vaccine is what type?

Answer 19

Inactivated

Question 20

Calicivirus morphology

Answer 20

Positive Sense RNA virus, naked virus

Question 21

Most common calicivirus

Answer 21

Norovirus (Norwalk)

Question 22

Norwalk manifestations

Answer 22

Diarrhea in crowded places, children, day care, schools, shellfish consumption

Explosive watery viral gastroenteritis

Question 23

Flavivirus structure

Answer 23

Enveloped RNA virus positive sense

Question 24

Dengue is what kind of virus

Answer 24

Flavivirus

Question 25

Breakbone fever is also known as

Answer 25

Dengue

Question 26

Yellow fever vector

Answer 26

Aedesaegypti

Question 27

Symptoms of fyerllow fever

Answer 27

Backache, jaundice, bloody dioarrhea, hematemesis

Question 28

West nile virus reservoir

Answer 28

birds

Question 29

Symptoms of west nile virus

Answer 29

Encephalitis, myelitis, meningitis, seizures

Question 30

Vector of West nile virus

Answer 30

Culex

Question 31

Flavivirus examples

Answer 31

Hep C Dengue West Nile Virus Yellow Fever

Question 32

Mechanism of antigenic variability in Hep C

Answer 32

3-5 exonuclease is noit proofread, so errors lead to antigentic variation

Question 33

Acute infection of Hep C marker

Answer 33

ALT rise and fall in 6 months, anti-HCV

Question 34

Chronic infection of Hep C marker

Answer 34

anti-HCV persists, cryoglobulin,

Question 35

Treatment of Hepatitis C

Answer 35

Ribavirin + IFN a,

Question 36

Two Examples of togavirus

Answer 36

Arbovirus, Rubella

Question 37

Three arbovirus examples

Answer 37

Western Equine, Venezuelan Equine, Eastern Equine Virus

Question 38

Symptoms of arbovirus

Answer 38

encephalitis

Question 39

Vector s of Arbovirus

Answer 39

Arthropods (nmosquitos)

Question 40

Togavirus morphology

Answer 40

Enveloped RNA virus pos sense

Question 41

Symptoms of rubella

Answer 41

postauricular, auricuulotemporal lymphadenopathy maculopapular rash beginning on face, spreading downard present for 3 days fever, fatigue,arthritis

Question 42

Transmission of rubella

Answer 42

Respiratory droplets

Question 43

Congenital Rubella Manifestations

Answer 43

PDA, congenital cataract, congenital deafness Mental retardation, miocrocephaly, , blindness, jaundice blueberry muffin rash

Question 44

Rubella vaccine type

Answer 44

Live attenuated

Question 45

HIV positive CD4 count needed before vaccination

Answer 45

CD4>200

Question 46

Coronavirus structure

Answer 46

Encapsulated RNA positive sense virus

Question 47

Shape of capsule of coronavirus

Answer 47

Helical

Question 48

Coronavirus example

Answer 48

Common cold, SARS, MERS, acute bronchitis

Question 49

HIV morphology

Answer 49

RNA single strand virus, enveloped, Diploid (2 RNA molecules for virion)

Question 50

HIV genes and function

Answer 50

gag , p24, RNA capsule env gene - envelope of virus makes glycoprotein 41 (transmembrane) and 120 (outer glycoprotein) pol gene - reverse transcriptase

Question 51

Cell which HIV imnitially infects

Answer 51

Macrophage and Helper T cells (CD4)

Question 52

Prodrome of HIV

Answer 52

Lymphadenopathy, fever, lasting for several weeks, self limiting

Question 53

Events on the latent period

Answer 53

HIV replicates in lymph nodes

Question 54

AIDS CD4 count cutoff

Answer 54

<200

Question 55

Malignancy caused bny HIV

Answer 55

Diffuse large B cell llymphomna

Question 56

Receptors ion cell whioch allow HIOV to enter CD4

Answer 56

CCR5, (early)CXCR4 (late)

Question 57

Diagnosis of HIV

Answer 57

Screening - Elisa Confirmation - Western Blot

Question 58

Drug for HIV in pregnant patients

Answer 58

Zidovudine