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PLE Microbiology > Viruses - RNA Neg Sense > Flashcards

Viruses - RNA Neg Sense Flashcards

1
Q

What is an RNA Negative Sense

A

THey have their own RNA polymerase to produce the positivesense which s transcribed

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2
Q

The only RNA virus that is double stranded is

A

Reovirus

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3
Q

Only RNA negative virus which repliates in the nucleus

A

Orthomyxovirus

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4
Q

Orthomyxovirus morphology

A

Enveloped RNA negative virus

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5
Q

Example of Orthomyxovirus

A

Influenza

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6
Q

How many segments does orthomyxovirus have

A

8

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7
Q

Antigenic drift vs shift

A

Drift - point mutation leading to change in hemagglutinin or neuramnidase

Shift - segments between species shift - reassortment, create new virus (bird flu, etc)

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8
Q

Influenza type causeing pandemics

A

Influenza A

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9
Q

f(x) of hemagluttinin

A

Binds on RBC togetherby binding of sialic acid residures. H1, H2, and H3 are found in humand

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10
Q

m2 protein function

A

Viral uncoating

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11
Q

f(x) of neuraminidase

A

CleaVES SIALIC ACID TO RELEASE CVIRIONS FROM CAPSULE

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12
Q

vACCINES FOR INFLUENZA

A

kILLED, im, lIVE ATTENUATED nASAL

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13
Q

Reye syndrome manifestations

A

Fatty liver, liver failure, encephalitis, fever, rash, vomiting once aspirain is given to patient with flu

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14
Q

Paramyxovirus morophgology

A

RNA single strasnded Negtative sense enveloped

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15
Q

Exampple of paramyxovirus

A

Measles

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16
Q

Symptoms of measles

A

Cough conjunctivitis, coryza, koplic spots (early, prodrome), fever up to 40

Maculopapular rash (may be confluent)- after prodromestart in ears –> face –> neck,, –> down

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17
Q

Measles complications

A

Pneumonia, SSPE

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18
Q

Virulence factoers in measles

A

HA,fusion protein – formaation of multinucleated giant cell (Warthin, Finkley cells) (inclusion bodies

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19
Q

Vitamminb which reduces morbidity and mortality im measles

A

Vitamin A

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20
Q

Manifestation of mumps

A

Lymphadenitis, unilateral orcvhitis, meningitis

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21
Q

Virulence factor of mumps

A

HA, NA, fusion protein

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22
Q

RSV age fgroup

A

Less than 6 months

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23
Q

Mechanism of infection of RSV

A

Attaches to G protein of lung epitheliaml spells

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24
Q

Disease associated with RSV

A

Pneumonia, bronchiolitis

25
Q

Virulence factors of RSV

A

Fusion protein

26
Q

Parainfluenaza causes what disease

A

Croup (barking cough)

27
Q

Virulence factors of parainfluenxza

A

Fusion, Na, Ha

28
Q

Steeple sign on Xray is associated with

A

Croup (parainfluenza)

29
Q

Morphology of rhabdovirus

A

RNA single strand negative sense enveloped bullet shaped

30
Q

Examples of rhabdovirus

A

Rabies

31
Q

Where does rabies virus replicate

A

Binds to nicotinic acetylcholine receptors in neurons of post sybaptic motor endplate

32
Q

Pathogenesis of rabies

A

Virus spreads retrograde from inoculation point to CNS

33
Q

Symptoms of rabies

A

Fever, encephalitis, drooling, salivation

34
Q

Negri bodies are found in

A

Rabies - eosinophilic cytoplasmic inclusion usually in hippocampus and pyramidal cells, purkinje cells

35
Q

Treatment for rabbies

A

Rabies Ig ASAP prior to onset of sx - passive immunization

Rabies vaccine - active immunization

36
Q

Filovirus morphology

A

Negative sense RNA single stranded helical capsid enveloped

37
Q

Example of filovirus

A

Marburg

Ebola

38
Q

Systems of filovirus

A

Hemorrhagic fever
Petechial rash
End organ failure
Hypovolemic shock

39
Q

Source of filovirus

A

Direct contact with monkeys or fruit bat

40
Q

Bunyavirus morphology

A

Single strand RNA negative sense enveloped

41
Q

Source of envelope of bunyavirus

A

Golgi

42
Q

Source of bunyavirus

A

Arthropods

43
Q

Hantavirus reservoir

A

Deer mouse

44
Q

Symptoms of hantavirus

A

Pulmonary capilalry leak
Prerenal azotemia
Hemorrhagix fever

45
Q

Bunyavirus arbovirus example

A

Rift valley fever - enceph, seizures

46
Q

Vector of california rift valley virus

A

Aedes

47
Q

Arenavirus morphology

A

Single strand negative sense RNA virus envelopef

48
Q

Ambisense RNA virus example

A

Arenavirus

49
Q

Source of arenavirus

A

Rodent transmission

50
Q

Examples of arenavirus

A

Lymphocytic choriomeningitis virus

51
Q

Synptons of arenavirus

A

Enceph

Fever

52
Q

Reovirus morphology

A

Naked double strabded RNA virus

53
Q

Segments of reovirus

A

11 (most number of segments)

54
Q

Example of reovirus

A

Rotavirus

55
Q

Mechanism of rotavirus

A

Toxin mediated watery diarrhea

56
Q

Toxin of rotavirus

A

NSP4 - increase chloride permeability

57
Q

Colorado tick fever manifestation

A

Fever myalgia rashes vomiting

58
Q

Examples of reovirus

A

Rotavirus

Colorado tick virus

59
Q

Rotavirus vaccine is

A

Live attenuated

PLE Microbiology (9 decks)

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