Viruses - RNA Neg Sense

Question 1

What is an RNA Negative Sense

Answer 1

THey have their own RNA polymerase to produce the positivesense which s transcribed

Question 2

The only RNA virus that is double stranded is

Answer 2

Reovirus

Question 3

Only RNA negative virus which repliates in the nucleus

Answer 3

Orthomyxovirus

Question 4

Orthomyxovirus morphology

Answer 4

Enveloped RNA negative virus

Question 5

Example of Orthomyxovirus

Answer 5

Influenza

Question 6

How many segments does orthomyxovirus have

Answer 6

8

Question 7

Antigenic drift vs shift

Answer 7

Drift - point mutation leading to change in hemagglutinin or neuramnidase

Shift - segments between species shift - reassortment, create new virus (bird flu, etc)

Question 8

Influenza type causeing pandemics

Answer 8

Influenza A

Question 9

f(x) of hemagluttinin

Answer 9

Binds on RBC togetherby binding of sialic acid residures. H1, H2, and H3 are found in humand

Question 10

m2 protein function

Answer 10

Viral uncoating

Question 11

f(x) of neuraminidase

Answer 11

CleaVES SIALIC ACID TO RELEASE CVIRIONS FROM CAPSULE

Question 12

vACCINES FOR INFLUENZA

Answer 12

kILLED, im, lIVE ATTENUATED nASAL

Question 13

Reye syndrome manifestations

Answer 13

Fatty liver, liver failure, encephalitis, fever, rash, vomiting once aspirain is given to patient with flu

Question 14

Paramyxovirus morophgology

Answer 14

RNA single strasnded Negtative sense enveloped

Question 15

Exampple of paramyxovirus

Answer 15

Measles

Question 16

Symptoms of measles

Answer 16

Cough conjunctivitis, coryza, koplic spots (early, prodrome), fever up to 40

Maculopapular rash (may be confluent)- after prodromestart in ears –> face –> neck,, –> down

Question 17

Measles complications

Answer 17

Pneumonia, SSPE

Question 18

Virulence factoers in measles

Answer 18

HA,fusion protein – formaation of multinucleated giant cell (Warthin, Finkley cells) (inclusion bodies

Question 19

Vitamminb which reduces morbidity and mortality im measles

Answer 19

Vitamin A

Question 20

Manifestation of mumps

Answer 20

Lymphadenitis, unilateral orcvhitis, meningitis

Question 21

Virulence factor of mumps

Answer 21

HA, NA, fusion protein

Question 22

RSV age fgroup

Answer 22

Less than 6 months

Question 23

Mechanism of infection of RSV

Answer 23

Attaches to G protein of lung epitheliaml spells

Question 24

Disease associated with RSV

Answer 24

Pneumonia, bronchiolitis

Question 25

Virulence factors of RSV

Answer 25

Fusion protein

Question 26

Parainfluenaza causes what disease

Answer 26

Croup (barking cough)

Question 27

Virulence factors of parainfluenxza

Answer 27

Fusion, Na, Ha

Question 28

Steeple sign on Xray is associated with

Answer 28

Croup (parainfluenza)

Question 29

Morphology of rhabdovirus

Answer 29

RNA single strand negative sense enveloped bullet shaped

Question 30

Examples of rhabdovirus

Answer 30

Rabies

Question 31

Where does rabies virus replicate

Answer 31

Binds to nicotinic acetylcholine receptors in neurons of post sybaptic motor endplate

Question 32

Pathogenesis of rabies

Answer 32

Virus spreads retrograde from inoculation point to CNS

Question 33

Symptoms of rabies

Answer 33

Fever, encephalitis, drooling, salivation

Question 34

Negri bodies are found in

Answer 34

Rabies - eosinophilic cytoplasmic inclusion usually in hippocampus and pyramidal cells, purkinje cells

Question 35

Treatment for rabbies

Answer 35

Rabies Ig ASAP prior to onset of sx - passive immunization | Rabies vaccine - active immunization

Question 36

Filovirus morphology

Answer 36

Negative sense RNA single stranded helical capsid enveloped

Question 37

Example of filovirus

Answer 37

Marburg | Ebola

Question 38

Systems of filovirus

Answer 38

Hemorrhagic fever Petechial rash End organ failure Hypovolemic shock

Question 39

Source of filovirus

Answer 39

Direct contact with monkeys or fruit bat

Question 40

Bunyavirus morphology

Answer 40

Single strand RNA negative sense enveloped

Question 41

Source of envelope of bunyavirus

Answer 41

Golgi

Question 42

Source of bunyavirus

Answer 42

Arthropods

Question 43

Hantavirus reservoir

Answer 43

Deer mouse

Question 44

Symptoms of hantavirus

Answer 44

Pulmonary capilalry leak Prerenal azotemia Hemorrhagix fever

Question 45

Bunyavirus arbovirus example

Answer 45

Rift valley fever - enceph, seizures

Question 46

Vector of california rift valley virus

Answer 46

Aedes

Question 47

Arenavirus morphology

Answer 47

Single strand negative sense RNA virus envelopef

Question 48

Ambisense RNA virus example

Answer 48

Arenavirus

Question 49

Source of arenavirus

Answer 49

Rodent transmission

Question 50

Examples of arenavirus

Answer 50

Lymphocytic choriomeningitis virus

Question 51

Synptons of arenavirus

Answer 51

Enceph | Fever

Question 52

Reovirus morphology

Answer 52

Naked double strabded RNA virus

Question 53

Segments of reovirus

Answer 53

11 (most number of segments)

Question 54

Example of reovirus

Answer 54

Rotavirus

Question 55

Mechanism of rotavirus

Answer 55

Toxin mediated watery diarrhea

Question 56

Toxin of rotavirus

Answer 56

NSP4 - increase chloride permeability

Question 57

Colorado tick fever manifestation

Answer 57

Fever myalgia rashes vomiting

Question 58

Examples of reovirus

Answer 58

Rotavirus | Colorado tick virus

Question 59

Rotavirus vaccine is

Answer 59

Live attenuated