Protozoa Flashcards

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1
Q

Mode of infection of Giardia

A

Fecal-oral transmission

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2
Q

Infective stage of Giardia

A

Cysts

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3
Q

Symptoms of Giardia

A

Foul smelling diarrhea

Steatorrhea

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4
Q

Trophozoite shape

A

Ventral Sucker, shield like shape

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5
Q

Trophozoitte mode of illness

A

Attach to intestine, nbut not invade

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6
Q

Diagnosis of Giardia

A

Stool O&P - trophozoites on stool

ELISA Stool antigen

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7
Q

Treatment of Giardia

A

Metronidazole

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8
Q

Transmission of Entamoeba Histolytica

A

Cysts from contaminated water

Anal sex

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9
Q

Trophozoite mode of action

A

Invade intestine, travel to liver, usually right lobe

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10
Q

Symptoms of Entamoeba histolytica

A
Liver abscess
Intestinal amoebiasis (bloody diarrhea, ulcerations
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11
Q

Flask shaped ulcers accociated with

A

Entamoeba histolytica

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12
Q

Diagnostic of Entamoeba histolytica

A

Trophozoites with endocytosed RBC in stool

Cysts / trophozoites in stool

ELISA for antibodies

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13
Q

Treatment of Entamoeba histolytica

A

Metronidazole

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14
Q

Luminal agents for entamoeba histolitica, for cysts

A

Paramycin

Iodoquinol

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15
Q

Most common cause of Diarrhea in HIV patient

A

Cryptosporidium

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16
Q

Morphology of cryptosporidum

A

Unicelluilar acid fast

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17
Q

Transmission of cryptosporidium

A

Ingestion of Cysts

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18
Q

Cysts of cryptosporidium contain how many sporozoites

A

4

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19
Q

Infection method of cryptosporidium

A

Sporozoites attach to intestinal wall

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20
Q

Treatment of Cryptosporidiuym

A

Nitrozoxanide

Spiramycin

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21
Q

Location of toxoplasma

A

Intracellular

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22
Q

Populatuions at risk for Toxoplasma

A

Pregnant, immunocompromised

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23
Q

Infection transmission

A

Uncooked meat containing cysts
Oocytes in animal feces
Transplacental

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24
Q

Clinical manifestations of Toxoplasma

A

Brain abscess with ring enhancing lesions on CT/MRI

Encephalitis

Congenital: Chorioretinitis, Calcifications in brain, Hydrocephalus, Seizure
Deafness

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25
Q

Brain enceph from Toxoplasma mimics what

A

CNS lymphoma

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26
Q

Diagnosis of Toxoplasmna

A

Serology\

Biopsy with intramuscular cysts

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27
Q

Treatment of Toxoplasmosis

A

Sulfadiazine, Pyrimethamine

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28
Q

Prophylaxis given for immunocompromised begins at what CD4 count to prevent Toxoplasma

A

<100

Cotrimoxazole

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29
Q

African sleeping sickness is caused by

A

Trypanosoma brucei

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30
Q

Trypanosoma brucei vector is:

A

Tsetse fly

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31
Q

Clinical manifestations of African sleeping sickness

A

Coma
Cervical lymphadenopathy
Recurrent fever, undulating

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32
Q

Diagnosis of Trypanosoma brucei

A

Trypomastigotes on blood smear, lymph node, or spine CSF

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33
Q

Mechanism of recurrent fever in Trypanosoma brucei

A

Antigenic variation

34
Q

Motility of Trypanosoma brucei

A

Flagella

35
Q

Treatment for Trypanosoma brucei

A

Melarsoprol - CNS

Suramin - peripheral blood

36
Q

Naegleria fowleri habitat

A

Freshwater

37
Q

Infection of Naegleria fowleri

A

phozoite enters nose from water sports or infected water / nasal irrigation–> cribriform plate –> infects CNS

38
Q

Clinical manifestations of Naegleria Fowleri

A

Meningoencephalitis

rapidly fatal

39
Q

Primary amebic meningitis is caused by?

A

Naegleria fowleri

40
Q

Diagnosis of Naegleria

A

Lumbar tap showing protozoan

41
Q

Treatment of Naegleria Fowleri

A

Amphotericin

42
Q

Chagas Disease is caused by

A

Trypanosoma cruzi

43
Q

Vector of Trypanosoma Cruzi

A

Kissing Bug Reduviid

44
Q

Infection mode of trypanosoma cruzi

A

Kissing bug feces dropped on human skin and human scratches,reaching bloodstream, and burrows on endocardium

45
Q

Clinical manifestations of Chagas Disease

A

Megacolon
Dilated cardiomyopathy
Mega esophagus

46
Q

Diagnosis of Chagas Disease

A

Blood smear during active infection

Serology
Trypanosomes on biopsy

47
Q

Treatment of Trypanosoma cruzi

A

Nifurtimox - acute

Chronic - none

48
Q

Parasite which causes malaria-like symptoms

A

Babesia

49
Q

Clinical symptoms of babesia

A

Hemolytic anemia, hemoglobinuria, jaundice, fever - irregularly cycling, sickle cell disease have higher risk

50
Q

Vector of babesia

A

Ixodes tick saliva

51
Q

Diagnosis of babesia

A

Thick blood smear

52
Q

Maltese cross appearance is?

A

Appearance of Babesia trophozoites in RBC

53
Q

Treatment of babesiosis

A

Atovaquone

Azithromycin

54
Q

Diagnosis of malaria

A

Blood smear with Giemsa stain

55
Q

Quartan feveln fever is associated with what plasmodium

A

Plasmodium malariae

56
Q

Dormant hypnozoites are formed in what malaria specie

A

P. Ovale

P. Vivax

57
Q

Tertian fever is found in what malaria

A

P. Ovale

P. Vivax

58
Q

Maralria causing irregular fever pattern

A

P. falciparum

59
Q

Malaria presenting with CNS symptoms

A

P. falciparum

60
Q

Morphology of P. falciparum

A

Banana shapoed in blood smear

61
Q

Anti malarial drug blocking plasmodium-heme

A

Chloroquine

62
Q

Antimalarial drug which destroyes hypnozoites, dormant cells in liver

A

Primaquine

63
Q

If chloroquine resistant, what drug do you use

A

Mefloquine, atovaquone, proguanil

64
Q

Treatment of P falciparumn

A

Artemesin + Quinidine

Coartemq

65
Q

Life cycle stage transmitted by anopheles

A

Sporozoites

66
Q

Sporozoites mature to what and where?

A

Trophozoites, liver

67
Q

Trophozoites matured in the liver spread by becoming?

A

Schizont, which divides to merozoites

68
Q

Life cycle in RBC

A

Merozoite matures again to trophozoite, become shizont and fivide into more merozoites, or it can produce gametocytes and divide sexually

69
Q

Ring form life cycle of malaria

A

Schizont

70
Q

Host of leishmania brazilensis

A

Vertebrates

71
Q

Cutaneous leishmaniasis are caused by

A

Leishmania braziliensis

72
Q

Vector of leishmania

A

Sandflies

73
Q

Transmission of leishmania

A

Sandfly - promastigote

Human - amastigote in macrophage

74
Q

Visceral leishmanaiasis is caused by

A

Leishmania Donovani

75
Q

Black fever oir Kala-azar is caused by

A

Leishmania Donovani

76
Q

Manifestations of visceralleishmaniasis

A

Hepatosplenomegaly

Pancytopenia

77
Q

Treatment of leishmaniasis

A

Stibugluconate - cutaneous

Amphotericin B - Visceral

78
Q

Cervicitis, strawberry cervix is associated with

A

Trichomonas vaginalis

79
Q

Symptoms of trichomonas

A

Burning, itching, yellow green discharge

80
Q

Diagnosis of Trichomonas

A

Wet mount - motile trophozoites

81
Q

pH of vaginal fluid infected with trichomonas

A

> 4.5

82
Q

Treatment of trichomonas

A

Metronidazole