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PLE Microbiology > Viruses - DNA Virus > Flashcards

Viruses - DNA Virus Flashcards

1
Q

Herpesvirus morphology

A

DNA virus enveloped double stranded linear

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2
Q

Cowdry bodies are

A

Intranuclear inclusion bodies found in nucleus herpesvirus infection

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3
Q

Transmission of herpes

A

Sex
Saliva
Vertical (torch)

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4
Q

Presentatiob of HSV-1

A

Gingivostomatitis turning to cold sores (herpes labialis), keratoconjunctivitis with serpigenous corneal ulcers

Temporal lobe encephalitis

Rashes
Erythema multiforme

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5
Q

HSV 1 remains latent in what structure

A

Trigeminal nerve

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6
Q

Dew drops on a rose petal rash is

A

Herpes (vesicles)

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7
Q

Herpetic whitlow is in what strictire

A

Fingers

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8
Q

HSV-2 manifestation

A

Painful inguinal lymphanopathy with vesicular lesions

Aseptic meningitis

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9
Q

HSV-2 lies dormant in

A

Sacral ganglia

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10
Q

Diagnosis of herpes

A

PCR

Tzanck smear - multinucleated giant cells

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11
Q

EBV morphology

A

Double stranded DNA

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12
Q

Infectious mononucleosis is caused by what virus

A

EBV

kissing disease

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13
Q

Symptomos of Infectious mononucleosis

A

Fever, tender lymphadenopathy (neck, can be generalized)
Splenomegaly
Pharyngitis and tonsilar exudates

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14
Q

Infectious mononucleosis mechanism

A

CD8 T cell mediated destructions, seeing Downey cells on blood smear from reactive lymphocytosis

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15
Q

EBV remains latent in what cells

A

B cell (by binding to CD21)of envelope glycoprotein

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16
Q

Effect if amox or ampi is given to infectious mono

A

Maculopapuilar rash

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17
Q

Cancers / other lesions associated with EBV

A

B cell lymphoma (Hodgkin mixed cellularity type, Burkitt lymphoma), Nasopharyngeal CA, Oral Hairy leukoplakia (NOT precancerous)

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18
Q

Diagnosis of EBV

A

Acute infectioon - Monospot test

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19
Q

Treatment of Infectious mononucleosis

A

Avoid contact sports to prevent splenic rupture

Other supportive management

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20
Q

CMV is in what family of viruses

A

Herpesvirus

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21
Q

Morphology of CMNV

A

Double stranded DNA

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22
Q

CMV remains latent in what cells

A

B and T cells, macrophages (mononuclear lymphocytes, then they are reactivaterd by immunospuppresion)

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23
Q

Congenital CMV manifestations

A

Bl;ueberry muffin rash (thrombocytopenia with petechiae)
Hepatosplenomegaly
Jaundice
Sensorineural daeafness
Intracranial calcifications, ventriculomegaly, (leading to seizurer and retardation)

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24
Q

Most Congenital CMV are asymptomatic? TRUE OR FALSE

A

TRUE

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25
What trimester is associated with high CMV transmission?
2nd
26
Hydrops fetalis is associated with what virus
CMV
27
Most common congenital viral infection
CMV
28
TrransplCMV infection in transplant patient?
CMV pneumonia
29
CMV infections in AIDS
``` CMV retinitis(pizza pie retinopathy), in CD4<50 CMV esophagitis, colitis ```
30
Owl eye inclusions is associated with what virus
CMV
31
Antiviral for CMV
Gancyclovir, Foscardin (for UL97 gene)
32
Varicella zoster morphology
Herpesvirus DNA virus double stranded Enveloped virus
33
Dewdrop on a rose petal describes
Vesicular rash (Herpexs simnpelx and varicella zoster)
34
Chickenpox vs smallpox rash
Chickenpox - all stages of healing | Smallpox - lesions all same stage
35
Diagnosis of varicella
Tzanck smear shows multinucleated giant cells
36
varicella infection complecations
Pneumonia, encephalitis, esp in immunocompromised
37
Varicella vaccine is?
Live attenuated
38
Varicella remains latent in which structure
Dorsal root ganglia
39
Reactivation of varicella occurs in
Stress, aging, or immunocompromised Herpes zoster, shingles
40
Disseminated herpes zoster virus manifests how
Herpes zoster crossing midline
41
Manifestations of herpes zoster
Dermatomal rash, painful Post herpetic neuralgia after rash vision loss if V1 is affected
42
Treatment of Shingles
Acyclovir, Famcyclovir, Valcyclovir
43
Congenital Varicella symptoms
Limb hypoplasia Cutaneous dermatomal scarring Blindness
44
Human Herpesvirus 6 causes?
Roseola (Sixth disease_
45
Structure of HHV
DNA virus, double stranded, enveloped
46
HHV-6 infects what cells in the body
CD4 cells - can cause immunosuppresion
47
Symptoms of Roseola (Exanthem subitem)
High fever up to 40 deg, 3-4 daYS, followed by diffuse macular rash, after fever subsides lacy appearance sparimng the face May cause febrile seizures
48
Treatment of Roseola
NONE. Supportive only Disease is self limiting
49
HHV-8 causes what disease
Kaposi Sarcoma
50
Manifestations of Kaposi sarcoma
Erythematous violaceous lesions from neovasularization in nose, extremities, and mucous membranes
51
Mechanism of Kaposi Sarcoma
Dysregulation of VEGF
52
Most common location of Kaposi Sarcoma
Hard palate
53
Malignancy associated with Kaposi Sarcoma
B Cell lymphoma (Primary Effusion Lymphoma)
54
Differential for Kaposi
Bartonella Henslae
55
Diagnosis of Kaposi
Lymphocytic infiltrate on microscopy. (Bartonella is neutrophilic)
56
Treatment of Kaposi Sarcoma
Antiretrovirals for HIV patients
57
Polyomavirus morphology
Naked circular DNA double stranded
58
Examples of Polyomavirus
JC and BK
59
Manifestation of JC virus
Progressive multifocal leukoencephalopathy (PML) in immunocompromised patients (CD4 < 200) - demyelination, nonenhancing lesion
60
Manifestation of BK virus
Nephropathy, Hemorrhagic cystitis, usually in transplant patients
61
HPV morphologyh
Double stranded DNA virus, naked
62
HPV 1-4 is associated with
Verruca vulgaris
63
HPV 6 and 11 are associated with
``` Laryngeal papillomatosis (children acquired in vaginal birth) Anogenital warts (Condyloma acuminata) - benign STI ```
64
HPV 16 and 18 are associated with
Anogenital cancers squamous cell (Vagina, vulva, cervix, anus, penile)
65
HPV 31 and 33 are associated with
Anogenital cancers squamous cell (Vagina, vulva, cervix, anus, penile)
66
HPV vaccine covers what strains
6,11,16,18 Inactivated cellular subunit vaccine
67
Most common STD
HPV
68
Genetic changes in HPV
E6 and E7 promotes proteolyses of p53 and RB respectively
69
Parvovirus morphology
Naked DNA single stranded virus
70
Smallest DNA virus
Parvovirus
71
Transmission of Parvovirus
Respiratory droplets, vertical transmission
72
Clinical symptoms of parvoviruyas
Slapped cheek disease (fifth disease, erythema infectiosum) - low grade fever for 1 week, then cheek rash after resolution of fever, then moves downward Joint pain, edema, arthritis in adults Transient aplastic anemia in sickle cell disease Congenital parvovirus - hydrops fetalis
73
Adenovirus morphologyh
Naked double stranded DNA virus
74
Clinical manifestations of adenovirus
Tonsillitis, adenoid infections Hemorrhagic cystitis Viral conjunctivitis
75
Transmission of adenovirus
Respiratory droplets | Fecal oral route, poor handwashing
76
Adenovirus vaccine
Live attenuated
77
Poxvirus morphology
DNA virus, largest known, dumbbell shapedcontains iessentaial matls, can make on envelopes, replicates in cytoplasm due to DNA dindependent RNA polymerase, does not need cell DNA to proliferate
78
Guarnieri bodies, inclusion bodies are associated with
Poxvirus site of rweplication
79
Vareola (smallpox ) manifestations
Vesicular lesions of the same age
80
Cowpox is acquired from
Infected cow udders
81
Molluscum contangiosujm is a what virus
Poxvirus
82
Hepatitis B virus morphology
Hepadnaviridae DNA virus, enveloped, replicates in both nucleus and cytoplasm circular DNA partially double stranded
83
Hepatitis B carries reverse transcriptase?? TRUE OR FALSE
TRUE
84
Extrahepatic manifestations of Hep B
Glomerulonephritis, polyarteritis Nodosa, purpuric rash, arthralgia,
85
Positive uring window period of Hepatitis B
Anti-Hbc (first antibody)
86
Hepatitis D morphology
RNA negative virus, enveloped, circular genome
87
Treatment for Hep B
Lamivudine\ NRTI Interferon alpha

PLE Microbiology (9 decks)

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