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PLE Microbiology > Viruses - DNA Virus > Flashcards

Viruses - DNA Virus Flashcards

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Biology 101 flashcards
1
Q

Herpesvirus morphology

A

DNA virus enveloped double stranded linear

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2
Q

Cowdry bodies are

A

Intranuclear inclusion bodies found in nucleus herpesvirus infection

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3
Q

Transmission of herpes

A

Sex
Saliva
Vertical (torch)

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4
Q

Presentatiob of HSV-1

A

Gingivostomatitis turning to cold sores (herpes labialis), keratoconjunctivitis with serpigenous corneal ulcers

Temporal lobe encephalitis

Rashes
Erythema multiforme

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5
Q

HSV 1 remains latent in what structure

A

Trigeminal nerve

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6
Q

Dew drops on a rose petal rash is

A

Herpes (vesicles)

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7
Q

Herpetic whitlow is in what strictire

A

Fingers

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8
Q

HSV-2 manifestation

A

Painful inguinal lymphanopathy with vesicular lesions

Aseptic meningitis

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9
Q

HSV-2 lies dormant in

A

Sacral ganglia

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10
Q

Diagnosis of herpes

A

PCR

Tzanck smear - multinucleated giant cells

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11
Q

EBV morphology

A

Double stranded DNA

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12
Q

Infectious mononucleosis is caused by what virus

A

EBV

kissing disease

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13
Q

Symptomos of Infectious mononucleosis

A

Fever, tender lymphadenopathy (neck, can be generalized)
Splenomegaly
Pharyngitis and tonsilar exudates

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14
Q

Infectious mononucleosis mechanism

A

CD8 T cell mediated destructions, seeing Downey cells on blood smear from reactive lymphocytosis

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15
Q

EBV remains latent in what cells

A

B cell (by binding to CD21)of envelope glycoprotein

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16
Q

Effect if amox or ampi is given to infectious mono

A

Maculopapuilar rash

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17
Q

Cancers / other lesions associated with EBV

A

B cell lymphoma (Hodgkin mixed cellularity type, Burkitt lymphoma), Nasopharyngeal CA, Oral Hairy leukoplakia (NOT precancerous)

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18
Q

Diagnosis of EBV

A

Acute infectioon - Monospot test

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19
Q

Treatment of Infectious mononucleosis

A

Avoid contact sports to prevent splenic rupture

Other supportive management

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20
Q

CMV is in what family of viruses

A

Herpesvirus

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21
Q

Morphology of CMNV

A

Double stranded DNA

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22
Q

CMV remains latent in what cells

A

B and T cells, macrophages (mononuclear lymphocytes, then they are reactivaterd by immunospuppresion)

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23
Q

Congenital CMV manifestations

A

Bl;ueberry muffin rash (thrombocytopenia with petechiae)
Hepatosplenomegaly
Jaundice
Sensorineural daeafness
Intracranial calcifications, ventriculomegaly, (leading to seizurer and retardation)

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24
Q

Most Congenital CMV are asymptomatic? TRUE OR FALSE

A

TRUE

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25
Q

What trimester is associated with high CMV transmission?

A

2nd

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26
Q

Hydrops fetalis is associated with what virus

A

CMV

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27
Q

Most common congenital viral infection

A

CMV

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28
Q

TrransplCMV infection in transplant patient?

A

CMV pneumonia

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29
Q

CMV infections in AIDS

A 
CMV retinitis(pizza pie retinopathy), in CD4<50
CMV esophagitis, colitis
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30
Q

Owl eye inclusions is associated with what virus

A

CMV

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31
Q

Antiviral for CMV

A

Gancyclovir, Foscardin (for UL97 gene)

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32
Q

Varicella zoster morphology

A

Herpesvirus DNA virus double stranded Enveloped virus

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33
Q

Dewdrop on a rose petal describes

A

Vesicular rash (Herpexs simnpelx and varicella zoster)

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34
Q

Chickenpox vs smallpox rash

A

Chickenpox - all stages of healing

Smallpox - lesions all same stage

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35
Q

Diagnosis of varicella

A

Tzanck smear shows multinucleated giant cells

36
Q

varicella infection complecations

A

Pneumonia, encephalitis, esp in immunocompromised

37
Q

Varicella vaccine is?

A

Live attenuated

38
Q

Varicella remains latent in which structure

A

Dorsal root ganglia

39
Q

Reactivation of varicella occurs in

A

Stress, aging, or immunocompromised

Herpes zoster, shingles

40
Q

Disseminated herpes zoster virus manifests how

A

Herpes zoster crossing midline

41
Q

Manifestations of herpes zoster

A

Dermatomal rash, painful
Post herpetic neuralgia after rash
vision loss if V1 is affected

42
Q

Treatment of Shingles

A

Acyclovir, Famcyclovir, Valcyclovir

43
Q

Congenital Varicella symptoms

A

Limb hypoplasia
Cutaneous dermatomal scarring
Blindness

44
Q

Human Herpesvirus 6 causes?

A

Roseola (Sixth disease_

45
Q

Structure of HHV

A

DNA virus, double stranded, enveloped

46
Q

HHV-6 infects what cells in the body

A

CD4 cells - can cause immunosuppresion

47
Q

Symptoms of Roseola (Exanthem subitem)

A

High fever up to 40 deg, 3-4 daYS, followed by diffuse macular rash, after fever subsides lacy appearance sparimng the face
May cause febrile seizures

48
Q

Treatment of Roseola

A

NONE. Supportive only Disease is self limiting

49
Q

HHV-8 causes what disease

A

Kaposi Sarcoma

50
Q

Manifestations of Kaposi sarcoma

A

Erythematous violaceous lesions from neovasularization in nose, extremities, and mucous membranes

51
Q

Mechanism of Kaposi Sarcoma

A

Dysregulation of VEGF

52
Q

Most common location of Kaposi Sarcoma

A

Hard palate

53
Q

Malignancy associated with Kaposi Sarcoma

A

B Cell lymphoma (Primary Effusion Lymphoma)

54
Q

Differential for Kaposi

A

Bartonella Henslae

55
Q

Diagnosis of Kaposi

A

Lymphocytic infiltrate on microscopy. (Bartonella is neutrophilic)

56
Q

Treatment of Kaposi Sarcoma

A

Antiretrovirals for HIV patients

57
Q

Polyomavirus morphology

A

Naked circular DNA double stranded

58
Q

Examples of Polyomavirus

A

JC and BK

59
Q

Manifestation of JC virus

A

Progressive multifocal leukoencephalopathy (PML) in immunocompromised patients (CD4 < 200) - demyelination, nonenhancing lesion

60
Q

Manifestation of BK virus

A

Nephropathy, Hemorrhagic cystitis, usually in transplant patients

61
Q

HPV morphologyh

A

Double stranded DNA virus, naked

62
Q

HPV 1-4 is associated with

A

Verruca vulgaris

63
Q

HPV 6 and 11 are associated with

A 
Laryngeal papillomatosis (children acquired in vaginal birth)
Anogenital warts (Condyloma acuminata) - benign STI
64
Q

HPV 16 and 18 are associated with

A

Anogenital cancers squamous cell (Vagina, vulva, cervix, anus, penile)

65
Q

HPV 31 and 33 are associated with

A

Anogenital cancers squamous cell (Vagina, vulva, cervix, anus, penile)

66
Q

HPV vaccine covers what strains

A

6,11,16,18

Inactivated cellular subunit vaccine

67
Q

Most common STD

A

HPV

68
Q

Genetic changes in HPV

A

E6 and E7 promotes proteolyses of p53 and RB respectively

69
Q

Parvovirus morphology

A

Naked DNA single stranded virus

70
Q

Smallest DNA virus

A

Parvovirus

71
Q

Transmission of Parvovirus

A

Respiratory droplets, vertical transmission

72
Q

Clinical symptoms of parvoviruyas

A

Slapped cheek disease (fifth disease, erythema infectiosum) - low grade fever for 1 week, then cheek rash after resolution of fever, then moves downward

Joint pain, edema, arthritis in adults

Transient aplastic anemia in sickle cell disease

Congenital parvovirus - hydrops fetalis

73
Q

Adenovirus morphologyh

A

Naked double stranded DNA virus

74
Q

Clinical manifestations of adenovirus

A

Tonsillitis, adenoid infections
Hemorrhagic cystitis
Viral conjunctivitis

75
Q

Transmission of adenovirus

A

Respiratory droplets

Fecal oral route, poor handwashing

76
Q

Adenovirus vaccine

A

Live attenuated

77
Q

Poxvirus morphology

A

DNA virus, largest known, dumbbell shapedcontains iessentaial matls, can make on envelopes, replicates in cytoplasm due to DNA dindependent RNA polymerase, does not need cell DNA to proliferate

78
Q

Guarnieri bodies, inclusion bodies are associated with

A

Poxvirus site of rweplication

79
Q

Vareola (smallpox ) manifestations

A

Vesicular lesions of the same age

80
Q

Cowpox is acquired from

A

Infected cow udders

81
Q

Molluscum contangiosujm is a what virus

A

Poxvirus

82
Q

Hepatitis B virus morphology

A

Hepadnaviridae

DNA virus, enveloped, replicates in both nucleus and cytoplasm
circular DNA partially double stranded

83
Q

Hepatitis B carries reverse transcriptase?? TRUE OR FALSE

A

TRUE

84
Q

Extrahepatic manifestations of Hep B

A

Glomerulonephritis, polyarteritis Nodosa, purpuric rash, arthralgia,

85
Q

Positive uring window period of Hepatitis B

A

Anti-Hbc (first antibody)

86
Q

Hepatitis D morphology

A

RNA negative virus, enveloped, circular genome

87
Q

Treatment for Hep B

A

Lamivudine\
NRTI
Interferon alpha

PLE Microbiology (9 decks)

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