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Path: Infectious Disease > Virus2 > Flashcards

Virus2 Flashcards

1
Q

minor diseases caused by non-polio enterovirus

A

URT and GI infection

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2
Q

serious complications of non-polio enterovirus

A

aseptic meningitis, encephalitis, myocarditis (coxsackie virus B)

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3
Q

when are non-polio enterovirus most common? how are they transmitted?

A

fall/summer; respiratory secretions or fecal-oral

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4
Q

this non-polio enterovirus causes myocarditis/pericarditis

A

coxsackie B

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5
Q

genome for coxsackie virus

A

ssRNA

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6
Q

this non-polio enterovirus is most closely associated with juvenile diabetes

A

coxsackie

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7
Q

characterized by vesicles in mouth (looking similar to herpes) –> caused by coxsackie virus

A

herpangina

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8
Q

infiltrate seen in myocarditis due to coxsackie B infection

A

lymphocytic

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9
Q

organism that most commonly causes hand, foot, and mouth disease

A

coxsackie virus A16

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10
Q

incubation period for HFM disease

A

3-7 days

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11
Q

this causes fifth disease *erythema infectiosum* –> slapped cheek rash, lacy red rash on trunk/limbs

A

parvovirus B19

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12
Q

slapped cheek rash, lacy red rash on trunk/limbs (may itch) –> associated with *aplastic anemia*

A

erythema infectiosum

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13
Q

major complication of erythema infectiosum due to parovirus B19 associated with sickle cell, other chronic diseases or immunosuppression (may be irreversible)

A

aplastic anemia

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14
Q

these non-polio enteroviruses resemble rubella (*important to distinguish from rubella so we know if there is outbreak to protect pregnant women*)

A

erythema infectiosum and roseola infantum

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15
Q

two major diagnostic criteria for roseola infantum

A

high fever and infant

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16
Q

polio enterovirus infects this tissue

A

oropharynx

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17
Q

this is inactive polio virus vaccine; requires booster, no risk of paralytic disease

A

salk

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18
Q

attenuated polio virus vaccine; risk of paralytic disease (especially Immunocompromised), greater duration immunity (induction IgA immunity in GI)

A

sabin

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19
Q

viruses that cause UR viral syndrome

A

adenovirus, rhinovirus, echovirus, coronavirus

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20
Q

viruses that cause LR viral syndrome

A

influenza, parainfluenza, RSV

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21
Q

viruses that cause GI tract/liver viral syndrome

A

rotavirus, norwalk, hepatitis

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22
Q

inclusions that are seen in adenovirus

A

cowdry type A intranuclear

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23
Q

only RNA virus that causes cancer (*due to chronic inflammation*)

A

hepatitis C

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24
Q

what does HSV I cause?

A

gingivostomatitis and cold sores (reactivation)

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25
Q

diagnostic procedure for herpes; what does this reveal if herpes present?

A

Tzacnk prep; inclusion-bearing multinucleated syncytia (giant cells)

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26
Q

these pathological features are associated with blisters/vesicles in herpes

A

edema and ballooning degeneration

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27
Q

this is major infectious cause of corneal blindness….also causes fatal sporadic encephalitis and can cause disseminated disease in immunocompromised

A

HSV1

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28
Q

symptoms caused by herpes TORCH infection

A

blindness, deafness, ataxia

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29
Q

herpes vesicles on fingers

A

herpetic whitlow

30
Q

latent infections of EBV

A

Burkitt’s lymphoma, B cell lymphoma, Nasopharyngeal carcinoma, sarcoidosis

31
Q

this disease will cause false positive mono-spot test (because does polyclonal activation B cells)

A

lupus

32
Q

these lymph nodes involved in enlargement and tenderness in infectious mono

A

cervical

33
Q

EBV binds to complement receptor on these cells

A

epithelial cells and B cells

34
Q

atypical lymphocytes in infectious mono

A

suppressor T cells

35
Q

these 3 things necessary for diagnosis of infectious mono

A

atypical lymphocytes, positive heterophile reaction, Ab for EBV

36
Q

most common opportunistic viral disease in AIDS patients

A

CMV

37
Q

aka genital warts

A

Condyloma accuminatum

38
Q

this virus causes Kaposi’s sarcoma

A

HHV8

39
Q

genome for HSV I/II

A

ds DNA

40
Q

these complications seen more commonly in older patients infected with infectious mono (EBV)

A

hepatitis, meningoencephalitis, pneumonitis

41
Q

EBV binds complement receptor on epithelial and B cells –> spread thru oral epithelium to what?

A

B lymphoid tissues

42
Q

see this in infectious mono due to the lymphoproliferation

A

lymphocytosis

43
Q

when do heterophile Ab (agglutinate RBC) peak in infectious mono? how long are they present?

A

2-3 weeks; 2-9 mo

44
Q

are heterophile Ab seen in infectious mono specific for EBV?

A

no (polyclonal activation)

45
Q

helps in diagnosis of CMV infection in neonates

A

CMV infected cells in urine sediment

46
Q

CMV infection is almost always accompanied by this infection in AIDS

A

Pneumocystis carinii

47
Q

CMV in immunosuppressed is associated with reactivation of viral infection that was latent in these cells

A

leukocytes

48
Q

HPV initially infects these cells

A

basal cells

49
Q

non-neoplastic strains of HPV associated with this

A

koliocytosis

50
Q

this virus is associated with multihemorrhagic manifestations, DIC, shock, death 30-90% –>death from hemorrhage, shock, fluid loss (although there is some visceral organ necrosis also)

A

ebola

51
Q

which neoplastic virus is considered nosocomial?

A

ebola

52
Q

this virus is transmitted to humans through rodent urine or feces –> acute hemorrhagic pulmonary syndrome (*mortality 50%*) –> fever, ARDS, hemorrhages, DIC

A

hanta

53
Q

this virus is transmitted thru Aedes mosquito –> causes hemorrhagic fever, thrombocytopenia, but more commonly myalgias, arthralgias, rash, NVD, fever, headache

A

dengue

54
Q

short-lived condition caused by WNV; what does it progress to in 1/150 infected individuals?

A

febrile illness (HA and myalgia); meingitis/encephalitis/meningoencephalitits

55
Q

these types of coxsackie virus cause viral meingitis, myocarditis/pericarditis (B only), herpangina, and acute onset juvenile diabetes

A

A23 and B6

56
Q

rash seen with Hand, Foot, Mouth disease

A

maculopapular, soles/palms, sometimes vesicles

57
Q

this is responsible for roseola infantum

A

HHV-6

58
Q

infant, high fever, lymphocytes w/ intranuclear inclusion bodies in CSF, maculopapular rash a few days following

A

roseola infantum

59
Q

inclusion bodies seen in Roseola infantum

A

intranuclear (in lymphocytes)

60
Q

where does polio (nonenveloped RNA) replicate initially?

A

intestinal mucosa and lymph nodes (1% invade CNS and multiply in motor neurons causing paralysis)

61
Q

receptors for polio virus

A

Ig superfamily

62
Q

these are responsible for hypersecretion seen in rhinovirus infection

A

bradykinins and inflammatory response

63
Q

these nonpolio enteroviruses spread oral-fecal, disseminate in blood after proliferation in lymphoreticular tissue, and primarily cause respiratory disorders

A

echovirus and coxsackie

64
Q

this protein on influenza binds to sialic acid containing proteins and lipids on most cells (mediates entry)

A

hemagglutinin

65
Q

infiltrate of submucosa seen in influenza virus infection

A

lymphomonocytic and plasmacytic

66
Q

causes croup (acute laryngotracheobronchitits)

A

parainfluenza 3

67
Q

most common cause of viral pneumonia in children

A

RSV

68
Q

these are seen within alveoli in RSV pneumonia infection

A

alveolar MP

69
Q

inclusions seen in adenovirus

A

Cowdry type A intranuclear

70
Q

common cause of ARDS and pneumonia in military recruits

A

adenovirus

71
Q

these cause pneumonias in immunosuppressed

A

CMV, varicella, HSV

72
Q

infectious diarrhea in infants/children –> most common in children being weaned (not getting mother’s IgA through milk anymore) –> destroys host epithelial cells

A

rotavirus

Path: Infectious Disease (10 decks)

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