Virus Families Flashcards
type of pathogen of virus
- obligate intracellular parasite
- can only replicate inside a host cell
outside of virus
- may be enveloped or naked
viral genomes
- DNA
- RNA
different steps in virus life cycle may provide
- targets for antiviral therapy
generic virus life cycle
- attachment
- entry
- uncoating
- synthesis of protein and nucleic acid
- assembly
- release
main components of viruses
- protein
- nucleic acids
- lipids
- sugars
virion
- entire virus particle
envelope
- may have glycoprotein spike
capsid
- protein coat surrounding inner part of virus
- basic unit of structure
nucleocapsid
- protein coat surrounding genome
capsomere
- subunit
envelope derived from
- host cell membranes
envelope contains
- virally encoded proteins that are usually glycoproteins
envelope glycoproteins form
- spike on surface
envelope virus morphology
- pleomorphic
- determined by cell of origin
functions of capsid proteins
- protects viral nucleic acid from environmental stress
- interacts specifically with viral nucleic acid for packaging
- interacts with host receptors for entry to cell
- release of nucleic acid upon entry into new cell
- viral and/or host gene regulation
how HIV is unique
- nucleocapsid and capsid
isocahedral viruses
- vast majority
isocahedral viruses shape
- spherical
isocahedral viruses limitation
- amount of nucleic acid limited by size of particle
- closed
helical virus shape
- rod-shaped
helical virus limitation
- no limit to amount of nucleic acid that can be packaged
- open
DNA viruses examples
- Poxviridae
- Herpesviridae
- Adenoviridae
- Papovaviridae
- Hepadnaviridae
- Parvoviridae
PHAP HP
viral genome functions
- genome replication
- genome assembly and packaging
- regulation of replication cycle
- modulation of host defenses
not in genome
- genes that encode for protein synthesis machinery
- energy metabolism
- membrane biosynthesis
outer envelope of enveloped virus composed of
- phospholipids
- proteins
- glycoproteins
enveloped virus released by
- budding
enveloped virus in heat, acids, drying
- sensitive
enveloped virus and GI tract disease
- less likely
non enveloped virus outer covering
- capsid protein
non enveloped virus released by
- lysis
noneveloped virus in heat, acids, dyring
- resistant
non enveloped virus in GI tract
- survive GI tract
which viruses are more likely to be latent
- DNA viruses
RNA virus replication more prone to
- errors
what do RNA viruses use for replication
- virus-encoded enzymes
what do DNA viruses use for replication
- host enzymes
example of grouping by disease process
- viral hepatitis
hep A virus
- picornavirus
- +ssRNA
hep B virus
- orthohepadnavirus
- dsDNA
hep C virus
- hepacivirus
- +ssRNA
hep D virus
- deltavirus
- -ssRNA
herpesvirus family examples
- HSV-1
- HSV-2
- VZV
- CMV
- EBV
alpha herpes viruses examples
- HSV-1
- HSV-2
alpha herpes virus action
- establish clinical latency in neuroglanglia
beta and gamma herpes virus action
- infect lymphocytic cells
primary infection HSV-1 HSV-2
- mouth or genital herpes
HSV-1 HSV-2 infection via
- direct contact
HSV-1 HSV-2 reactivation
- cold sore
- genital herpes
VZV which one more contagious
- chickenpox
varicella complication
- bacterial superinfection
- pneumonitis
- hepatitis
- encephalitis
clue for varicella infection
- unilateral on one side
- band on back
- painful
symptomology of CMV
- asyptomatic
- can be infectious mono
disease of CMV
- congenital infections
- disease in immunocompromised
EBV cause
- infectious mononucleosis
Influenza A virus group
- orthomyxovirus
influenza A virus nucleic acid
- -ssRNA
- segmented
another important virus with a segmented genome
- rotavirus
subtypes named based on
- envelope hemagglutinin
- neuraminidase