Immunosuppressants and Immunomodulators Flashcards
immunosuppressant definition
- drugs that increase risk of infection
immunosuppressants target - broad/narrow
- broad targets/effects
age of immunosuppressant drugs
- old drugs
immunomodulators definition
- drugs that DO NOT increase risk of infection
Immunomodulators target - broad/narrow
- narrow targets/effects
age of immunomodulator drug
- new drugs
four characteristics of an inflammatory immune response
- pain (dolor)
- heat (calor)
- erythema (rumor)
- swelling (tumor)
eicanosanoids synthesized by
- most cells
eicanosanoids role in inflammation
- act as local vasodilators
what molecules do drugs affect in eicosanoid production/activity?
- prostaglandins
- leukotrienes
what molecules do drugs affect in inflammatory cytokine production/activity
- TNFa
- IL-2
- IL-5
- IL-6
what molecules do drugs affect in leukocyte activation/proliferation?
- Th-cells
- B-cells
- eosinophils
- mast cells
what are eicosanoids derived from?
plasma membrane lipids
what creates arachidonic acid
- from plasma membrane lipids
- by phospholipase A2
what are the three eicosanoids derived from arachidonic acid?
- prostaglandin E2
- Thromboxane A2
- Leukotriene E4
prostaglandins E2 produced by
- most cells
thromboxane A2 produced by
- platelets
leukotriene E4 produced by
- leukocytes
cyclooxygenase inhibitors inhibit what process
- synthesis of prostanoids
big class of COX inhibitors
- NSAIDs
COX1 constitutive/inducible
- constitutive
COX1 responsible for
- homeostatic functions
COX2 constitutive/inducible
- inducible
COX2 responsible for
- inflammatory response