Hypersensitivity Flashcards
Hypersensitivity
defect in regulation or targeting of the usually beneficial immune response
i.e. overreaction of normal immune response triggered by self/microbial/environmental antigens
Triggers of hypersensitivity
3 types of antigens
- “self” antigens -autoimmunity
- microbial antigens - excessive inflammation
- Environmental antigens - allergy/atopy
What are the 4 types of hypersensitivity?
Type I - Immediate hypersensitivity
Type II - Antibody-mediated
Type III - Immune complex-mediated
Type IV - T cell-mediated
Names for Type 1 Hypersensitivity
Immediate, IgE-mediated, allergy/atopy
Timing of Type 1 Hypersensitivity
within minutes (very rapid)
Mechanism of Type 1 Hypersensitivity
cross-linking of IgE triggering mediator release in mast cells
Involve antigen-specific IgE on effector cells
Various mediators in Type 1 Hypersensitivity
vasoactive mediators (e.g. histamine)
lipid mediators
cytokines
Most common type of hypersensitivity
Type 1
Allergy =
histamine
Examples of allergic diseases (Type 1 Hypersensitivity)
- Allergic rhinitis (“hay fever”)
- Atopic asthma
- Anaphylaxis (food allergy, stinging insect allergy, drug allergy)
Potential causes of increase in Type 1 Hypsersensitivity prevalence within the past 50 years
- hygiene hypothesis
- environmental factors
Similarities between Type II and III hypersensitivity
both mediated by antibodies (involve IgG and IgM)
frequently involve auto-antibodies (failure in developing or loss of self-tolerance)
less commonly involve foreign antigens
Type II Hypersensitivity
- Injury related to antibody directly binding to target
- Antigens are specific cells or extracellular matrix
Differences between Type II and III Hypersensitivity
Type II: Local, tissue/cell specific (i.e. “targeted”)
Type III: Systemic
Type III Hypersensitivity
- Injury related to immune complex deposition
- Antigens are present in circulation
Names for Type II Hypersensitivity
antibody-mediated, cytotoxic
Timing for Type II Hypersensitivity
couple days up to a week
Mechanism of Type II Hypersensitivity
3 mechanisms:
- complement/Fc receptor inflammation
- opsonization/phagocytosis
- receptor activation
1st mechanism of Type II Hypersensitivity
“Complement- and Fc receptor-mediated inflammation”
Antibody binds antigens and attract neutrophils and/or complement which lead to inflammation and injury
Goodpasture syndrome
Anti-glomelular basement membrane disease
What are antibodies directed against in Goodpasture syndrome?
Abs against basement membrane in kidney and lung
Activate complement and Fc receptors (of neutrophils), leading to inflammation
Symptoms of Goodpasture syndrome
Blood in urine, Blood in lung, kidney failure and fatigue