Virology IV Flashcards
3 genes of HIV
structural
env - gp120 and gp41
gag - p24
pol - reverse transcriptase, aspartate protease, integrase
HIV reverse transcriptase
synthesize dsDNA from genomic RNA
dsDNA - integrated to host genome
HIV binding
gp120 - attachment to CD4+ cells
gp41 - transmembrane - fusion and entry to cell
capsid protein HIV
p24
coreceptor HIV binding
binds to CD4 - needs coreceptor
macros - CCR5 - early infection
T cells - CXCR4 - late infection
homozygous CCR5 mutation
immune HIV
heterozygote - slower course
diagnosis of HIV
ELISA - rule out test
western blot - rule in test
diagnosis of AIDS
CD4 less than 200
anti-gp120
cross placenta
infection in HIV positive - CD4 less than 500
candida EBV bartonella hencellae HHV-8 cryptosporidium HPV
HIV candida
CD4 less than 500
HIV EBV
CD4 less than 500
HIV bartonella henselae
CD4 less than 500
HIV HHV8
CD4 less than 500
HIV cryptosporidium
CD4 less than 500
HIV HPV
CD4 less than 500
HIV CD4 less than 200
toxoplasma gondii
HIV
JC virus
pneumocystic jirovecii
HIV toxoplasma gondii
CD4 less than 200
HIV HIV infection
CD4 less than 200
HIV JC virus
CD4 less than 200
HIV pneumocystic jirovecii
CD4 less than 200
HIV patient CD4 less than 100
aspergillus cryptococcus neoformans candida albicans CMV EBV histoplasma capsulatum mycobacterium avium intracellulare
HIV aspergillus
CD4 less than 100
HIV cryptococcus neoformans
CD4 less than 100
HIV candida albicans
CD4 less than 100
HIV CMV
CD4 less than 100
HIV EBV
CD4 less than 100
HIV histoplasma capsulatum
CD4less than 100
HIV myobacterium avium intracellulare
CD4 less than 100
prion disease
alpha-helical protein - to beta-pleated form
PrP-C to PrP - SC
resistant to sterilizing procedures - including autoclave
spongiform encephalopathy
prio disease
creutzfeldt jakob disease
rapid progressive dementia
typically sporadic
prion disease
bovine spongiform encephalitis
prion disease
aka mad cow disease
kuru
acquired prion disease
cannibals - who eat brains
