Mycology I Flashcards
dimorphic fungi at temp
cold - mold
heat - yeast
except cocidiomycosis - spherule in tissue
tx for local mycosis infection
flucanozole
itraconazole
tx for systemic mycosis infection
amphotericin B
mississippi and ohio river valley, pneumonia, macrophage filled
histoplasmosis
histoplasmosis
mississippi and ohio river valley
fills macrophages
bird and bat poo
blastomycosis
east of mississippi river and central america
inflammatory lung disease - disseminate skin and bone
granuloma nodules form
coccidiomycosis
southwest US, Cali
pneumonia and meningitis
increased rate after earthquake - dust to air
spherule filled with endosores
coccidiomycosis
captains wheel formation
paracoccidiomycosis
in latin america
budding yeast
cutaneous mycosis
tinea
cutaneous fungal infection
dermatophyte
tinea
dermatophytes
cause tinea
microsporum, trichophyton, epidermophyton
microsporum
dermatophyte - cutaneous fungal infection
trichophyton
dermatophyte - cutaneous fungal infection
epiermophyton
dermatophyte - cutaneous fungal infection
tinea capitis
head/scalp fungal infection
dermatophyte
tinea corporis
body fungal infection
dermatophyte
tinea cruris
inguinal area fungal infection
dermatophyte
tinea pedis
foot fungal infection
3 varieties:
1 interdigital MC
2 mocassin
3 vesicular
tinea unguium
nailbed fungal infection
aka onychomycosis
onychomycosis
nailbed fungal infection
tinea unguium
tinea versicolor
from malassezia species
-yeast like fungus
tinea versicolor path
degradation of lipid produces acids - damage melanocytes
-reults in hypopigmented and pink patches
often in summer and hot-humid weather
spaghetti and meatballs on microscopy
tinea versicolor - malassezia
oral thrush
candida in immunocompromised
endocarditis in IV drug user
candida
tx of candida
topical azole - vaginal
nystatin, flucanozole, or caspofungin - oral thrush
flucanozol, caspofungin, ampho B - systemic
germ tube at 37C
candida albicans
pseudohyphae and budding yeast at 20C
candida albicans
septate hyphae branch at 45 egrees
aspergillus fumigatus
aspergilloma
in lung cavity - after TB
aflatoxins
produced by aspergillus species
-associated with hepatocellular carcinoma
allergic bronchopulmonary aspergillosis
asthma and CF association
bronchiectasis and eosinophilia
india ink stain with halos
cryptococcus neoformans
cryptococcus neoformans
heavily capsuled yeast
-soil and pigeon droppings
pigeon droppings
cryptococcus neoformans
sabouraud agar
culture of cryptococcus neoformans
soap bubble lesion in brain
cryptococcus neoformans
mucormycosis
diabetic ketoacidosis
mucor and rhizopus specie
fungi proliferate blood vessel wall - penetrate cribriform plate - enter brain
rhinocerebral frontal lobe abscess
HA, facial pain, black necrotic eschar on face
tx of mucormycosis
surgical debridement
amphotericin B
pneumocystis pneumonia
diffuse interstitial pneumonia
-with pneumocystis jirovecii
get disease if immunosuppressed (ex/ AIDs)
CXR for pneuomcystis pneumonia
B/L ground glass opacities
diagnosis - lung biopsy or lavage
disc shaped yeast on methenamine sliver stain
pneumocystic jirovecii
tx pneumocystis jirovecii
TMP-SMX
pentamide
dapsone (prophylaxis)
atovaquone (prophylaxis)
prophylaxis in HIV for pneumocystis
dapsone and atovaquone
if CD4
rose gardener gets pustule and ulcer along lymphatics
sporothrix schenckii
sporothrix schenckii
dimorphic
cigar shaped budding yeast
tx sporothrix
itraconazole
potassium iodide