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Board Review - B - Microbiology > Virology I > Flashcards

Virology I Flashcards

1
Q

viral structure

A

capsid - icosahedral or helical

enveloped or non-enveloped

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2
Q

recombination

A

exchange genes between 2 chromosomes

-crossing over within regions of significant base homology

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3
Q

reassortment

A

virus exchange genetic material

ex. H1N1 influenza A

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4
Q

complementation

A

1 of 2 viruses infecting cell mutation results in nonfunctional protein

making functional protein that serves both viruses

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5
Q

Hep B and Hep D

A

Hep D requires presence of replicating hep B virus
-provides HBsAg - envelope protein for Hep D

ex. of complementation

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6
Q

phenotypic mixing

A

simultaneous infection of cell with 2 viruses

form hybrid virus

  • virus A with surface protein virus B
  • type B coat - determine infectivity
  • progeny from this infection - has virus A coat again
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7
Q

live attenuated vaccines

A 
smallpox
yellow fever
rotavirus
chickenopx
sabin polio virus
MMR
influenza (intranasal)

“mMR. I. Sabin, the Small Yellow Rotating Chicken.”

dangerous to give to immunocompromised pts

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8
Q

Mr. I Sabin, the Small Yellow Rotating Chicken

A 
MMR
influenza (intranasal)
Sabin polio virus
smallpox
yellow fever
rotavirus
chickenpox

live attenuated vaccines

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9
Q

killed viral vaccine

A

rabies, influenza (injected)
salk polio
HAV

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10
Q

HBV vaccine

A

HBsAg

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11
Q

HPV vaccine

A

subunit

-type 6, 11, 11, 16, 18

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12
Q

parvovirus

A

only DNA virus single strand

” part of a virus”

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13
Q

reoviridae

A

only RNA virus double strand

“repeat-o-virus”

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14
Q

most DNA virus

A

dsDNA

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15
Q

most RNA virsu

A

ssRNA

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16
Q

“I went to a retro toga party where I drank flavored corona and ate hippy california pickles.”

A

positive strand RNA viruses

retrovirus
togavirus
flavivirus
coronavirus
hepevirus
calicivirus
picornavirus
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17
Q

positive strand ssRNA

A

equal to mRNA

-no need for polymerase

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18
Q

require polymerase

A

negative strand ssRNA and dsRNA

19
Q

DNA virus replication

A

in nucleus

except poxvirus

20
Q

RNA virus replication

A

in cytoplasm

except influenza and retrovirus

21
Q

non-enveloped viruses

A

give PAPP smears and CPR to a naked hippy

naked - non-enveloped

DNA - PAPP - papillomavirus, adenovirus, parvovirus, polyomavirus

RNA - CPR hippy - calcivirus, picornavirus, reovirus, hepevirus

22
Q

herpes virus envelope

A

gets envelope from nuclear membrane

23
Q

enveloped virus get envelope

A

from plasma membrane

exception - herpes - gets from nuclear membrane

24
Q

HHAPPPPy

A

DNA viruses

hepadna
herpes
adeno
pox
parvo
papilloma
polyoma
25
Q

DNA viruses are generally

A

double strand
linear
icosahedral
replicate in nucleus

26
Q

poxvirus

A

complex - not icosahedral

does not replicate in nucleus - has own DNA-dependent RNA polymerase

27
Q

circular DNA viruses

A

hepadna
papilloma
polyoma

28
Q

molluscum contagiosum

A

poxvirus - dsDNA linear DNA virus
-largest DNA virus

flesh colored papule with central umbilication

29
Q

progressive multifocal leukencephalopathy in HIV

A

with JC polyomavirus

JC - junky cerebrum

30
Q

BK polyomavirus

A

target kidney transplant patient

BK - bad kidney

31
Q

HPV

A

papillomavirus

dsDNA virus - circular

32
Q

fifth disease

A

parvovirus B19
-ssDNA linear - smallest DNA virus

slapped cheek rash in children
-erythema infectiosum

33
Q

aplastic crisis in sickle cell

A

parvovirus B19

34
Q

pink eye

A

adenovirus

dsDNA linear

35
Q

acute hemorrhagic cystitis

A

adenovirus

36
Q

herpes simplex 1

A

oral lesions
spontaneous temporal lobe encephalitis
keratoconjunctivitis

37
Q

herpes simplex 2

A

genital lesions

38
Q

herpes simplex 3

A

varicella zoster

  • chickenpox
  • zoster (shingles)
39
Q

herpes simplex 4

A

EBV

-mono, burkitt, hodgkin, nasopharyngeal carcinoma

40
Q

herpes simplex 5

A

CMV - immunocompromised infection

-AIDS retinitis

41
Q

herpes simplex 6

A

roseola - exanthem subithum

42
Q

herpes simplex 7

A

less common cause roseola

43
Q

herpes simplex 8

A

kaposi sarcoma

44
Q

herpes virus

A

dsDNA linear

Board Review - B - Microbiology (16 decks)

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