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Systems 3 - Neuro > Viral infections > Flashcards

Viral infections Flashcards

1
Q

meningitis (no cutaneous lesions)

A

varicella zoster (reactivation, shingles)

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2
Q

meningitis - young children

A

parecho virus

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3
Q

meningitis - plus or minus parotitis

A

mumps

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4
Q

meningitis enterovirus (Non specific flu like symptoms)

A

poliovirus

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5
Q

meningitis other

A

HSV 2

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6
Q

encephalitis - retrovirus

A

HIV 1 + 2

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7
Q

encephalitis - herpes

A

vzv
hsv1
hhv6

immunocomprimised
ebv/cmv

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8
Q

encephalitis - rare

A

rabies

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9
Q

encephalitis - equine borne, eastern, western, venezualan

A

togavirus

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10
Q

encephalitis - tick borne - west nile and europe

A

Flavivirus (Japanese B)

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11
Q

infection of spinal cord

A

HIV

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12
Q

myelitis and reticulitis

A

VZV/CMV ( secondary to HIV?)

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13
Q

infections of spinal cord, drg and brainstem

A

poliovirus and HTLV1/2

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14
Q

mildest infection

A

enterovirus (often self limiting)

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15
Q

most severe infection

A

HSV

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16
Q

can cause paralytic polio, faecal oral

A

enterovirus

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17
Q

aseptic meningitis caused by…

A

enterovirus

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18
Q

aseptic meningitis due to… (3)

A

inflamm eg SLE/sarcoid
chronic inflam eg BMT/chemo/agammaglobulinaemia
partially treated bacterial meningitis

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19
Q

aseptic meningitis most common in…

A

under 40s - babies

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20
Q

aseptic meningitis features (6)

A 
no altered neuro function
sore throat
nandv
headache
neck stiffness
photophobia
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21
Q

aseptic meningitis presentation - neonates (5)

A 
irritable
fever
off food
abnormal LFT
normal CSF
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22
Q

aseptic meningitis complication

A

fulminant multi organ failure

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23
Q

CSF changes enterovirus - white cells

A

very elevated lymphocytes

24
Q

CSF changes enterovirus - protein

A

0.45-0.9

25
Q

CSF changes glucose enterovirus

A

1.0-1.7 below serum

26
Q

enterovirus CSF changes could indicate… (3)

A

tb
lymphocytic leukaemia
abcess

27
Q

enterovirus management

A

symptomatic
good prognosis
may be recurrent if HSV

28
Q

sporadic encephalitis causes (3)

A

hsv1/2
EBV
VZV

29
Q

hsv location

A

temporal lobe
ipsilateral olfactory nerve

(unilateral oribtofrontotemporal) diffuse in children

30
Q

cowdry a inclusions (nuclear DNA)

A

hsv1/2

31
Q

infection in utero/parturition - genital infection shedding

A

HSV2

32
Q

HSV1
HSV2
which recurrs more often?

A

HSV2

33
Q

winter and spring sporadic encephalitis

A

VSV

34
Q

sporadic encephalitis along sensory nerves to ganglia

A

vsv (shingles)

35
Q

rare respiratory spread of sporadic encephalitis

A

VZV

36
Q

GBS complication

A

vzv

37
Q

opthalmalgic trigeminal pain, dysaesthesia before rash, persistent pain

A

VZV

38
Q

CSF pleocytosis and inc protein

A

EBV

39
Q

complications of ebv (7)

A 
aseptic meningitis
encephalitis
gbs
bells palsy
transverse myelitis
acute cerebellar syndrome
40
Q

lymphoma can develop if immunocomprimised

A

EBV

41
Q

EBV - easy or difficult to recover?

A

difficult

42
Q

post infectious encephalitis - rare (5)

A

measles, mumps, rubella, chickenpox, influenza

43
Q

chronic progressive encephalitis (2)

A

hiv
rabies

sspe
pml

44
Q

SSPE symptoms

A

dementia, motor disturbance, cerebellar ataxia, myoclonic jerks, seizures, focal retinopathy

45
Q

SSPE age

A

7-8y/o (3:1 M:F)

46
Q

PML virus

A

papovavirus

47
Q

PML pathology

A

kills oligos, transforms astrocytes, white matter necrosis

48
Q

PML inital infection

A

GI/resp

49
Q

PML virus found in…

A

urine and throat

50
Q

PML symptoms

A

visual, motor, cognitive and speech probs - death in 3-6months

51
Q

PML treatment

A

no cytosine arabinoside
no JCV antigen
no serology

must restore immunocompetence

52
Q

Epidemic encephalitis characteristics (3)

A

seasonal
tick borne?
mosquitoes?

53
Q

detect vzv/hsv by…

A

pcr

54
Q

detect enterovirus/arbovirus by…

A

csf

55
Q

CNS SOL manifestations of hiv

A

toxoplasmosis, lymphoma, PML, tuberculoma

56
Q

CNS diffuse manifestations of hiv

A

cryptococcal, meningitis, acute infection, dementia

57
Q

sspe virus

A

measles

Systems 3 - Neuro (14 decks)

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