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Systems 3 - Neuro > Antidepressants > Flashcards

Antidepressants Flashcards

1
Q

isoniazid, phenelzine, tranylcypromine

A

MAOI (irreversible)

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2
Q

mocolobemide

A

MAOI (reverisble)

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3
Q

MAO A

A

5HT

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4
Q

MAO B

A

DA/NA

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5
Q

MAOI side effects (5)

A

M1,H1,alpha1,5HT2, cheese reaction

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6
Q

drug interactions with MAOI

A

amphetamine
alcohol
pethidine (opioid)
anaesthetics

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7
Q

amitryptiline

A

NA/5HT TCA

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8
Q

desipramine

A

NA TCA

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9
Q

clomipramine

A

5HT TCA

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10
Q

TCA side effects (5)

A

H1,M1,5HT2,alpha1, cardiotoxicity

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11
Q

fluoxetine, paroxetine, citalopram

A

ssri

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12
Q

reboxetine

A

snri

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13
Q

fluoxetine side effects

A

5HT

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14
Q

reboxetine side effects

A

M and NA

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15
Q

sertraline

A

ssri - best acceptability and efficacy

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16
Q

discontinuation syndrome common in…

A

peroxetine

17
Q

venlafaxine

A

atypical - snri and 5ht antag for non responders/ extreme, weight gaining, retarded, hypersomniac

18
Q

trazedone

A

atypical - ssri and 5ht2 antag

19
Q

mirtazapine

A

na and 5ht antag, inc na autoreceptors

20
Q

agomelatine

A

atypical - melatonin agonist and 5ht2 antag

21
Q

ketamine

A

NMDA antag for treatment resistant patients (1x per week, with typical)

22
Q

lithium

A

mood stabiliser

reduce glut (replace na+)
gene expression
2nd messangers

23
Q

lithium side effects(7)

A

teratogenic, arrythmias, nausea, hypothyroid, tremor, dysarthria, ataxia

24
Q

valproate, carbemazepine

A

anticonvulsants (+mood stabiliser)

25
Q

haloperidol (acute), olanzapine (longterm)

A

antipsychotics as mood stabilisers

26
Q

valproate side effects (6)

A 
inc liver transaminase
nausea
diarrhoea
ataxia
dysarthria
weight gain
27
Q

carbemazepine side effects (5)

A 
dizziness
sedation
ataxia
leukopenia
rash
28
Q

lithium action - bipolar

A

block ipp and impase

29
Q

vpa action - bipolar

A

block gluc-6-p –> IP1 via ino-1

30
Q

post synaptic agonist

A

busiprone

31
Q

nefazedone

A

snri/ssri and 5ht2 antag

Systems 3 - Neuro (14 decks)

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