Antidepressants Flashcards
isoniazid, phenelzine, tranylcypromine
MAOI (irreversible)
mocolobemide
MAOI (reverisble)
MAO A
5HT
MAO B
DA/NA
MAOI side effects (5)
M1,H1,alpha1,5HT2, cheese reaction
drug interactions with MAOI
amphetamine
alcohol
pethidine (opioid)
anaesthetics
amitryptiline
NA/5HT TCA
desipramine
NA TCA
clomipramine
5HT TCA
TCA side effects (5)
H1,M1,5HT2,alpha1, cardiotoxicity
fluoxetine, paroxetine, citalopram
ssri
reboxetine
snri
fluoxetine side effects
5HT
reboxetine side effects
M and NA
sertraline
ssri - best acceptability and efficacy
discontinuation syndrome common in…
peroxetine
venlafaxine
atypical - snri and 5ht antag for non responders/ extreme, weight gaining, retarded, hypersomniac
trazedone
atypical - ssri and 5ht2 antag
mirtazapine
na and 5ht antag, inc na autoreceptors
agomelatine
atypical - melatonin agonist and 5ht2 antag
ketamine
NMDA antag for treatment resistant patients (1x per week, with typical)
lithium
mood stabiliser
reduce glut (replace na+)
gene expression
2nd messangers
lithium side effects(7)
teratogenic, arrythmias, nausea, hypothyroid, tremor, dysarthria, ataxia
valproate, carbemazepine
anticonvulsants (+mood stabiliser)
haloperidol (acute), olanzapine (longterm)
antipsychotics as mood stabilisers
valproate side effects (6)
inc liver transaminase nausea diarrhoea ataxia dysarthria weight gain
carbemazepine side effects (5)
dizziness sedation ataxia leukopenia rash
lithium action - bipolar
block ipp and impase
vpa action - bipolar
block gluc-6-p –> IP1 via ino-1
post synaptic agonist
busiprone
nefazedone
snri/ssri and 5ht2 antag
