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Systems 3 - Neuro > Cognitive enhancers > Flashcards

Cognitive enhancers Flashcards

1
Q

serotonin nucleus

A

raphe

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2
Q

dopamine nuclei

A

sub nigra, VTA

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3
Q

NA nucleus

A

locus ceruleus

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4
Q

NA action

A

attention and arousal

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5
Q

Serotonin action

A

impulse control and cognitive flexibility

loss in schizophrenia

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6
Q

Dopamine action

A

reward and learning

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7
Q

NA, 5HT, DA action

A

cognition and emotion

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8
Q

NA AND 5HT action

A

anxiety and irritability

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9
Q

5HT and DA action

A

appetite and aggression

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10
Q

NA and DA action

A

motivation

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11
Q

inhibit reputake NA>DA/5-HT

A

atomoxetine (ADHD)

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12
Q

inhibit reuptake NA/DA>5-HT

A

methylphenidate (ADHD)

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13
Q

inhibit reuptake DA>NA»5-HT

A

bupoprion (smoking cessation)

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14
Q

inhibit reuptake 5-HT>NA»DA

A

venlafaxine (anxiety/depression)

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15
Q

inhibit reuptake 5-HT»NA»DA

A

sertraline (depression/anxiety)

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16
Q

reuptake inhibitors for anxiety

A

SSRI and TCA

17
Q

reuptake inhibitors for eating disorders

A

anorexia and bulemia - SSRI

obesity - amphetamine and sertraline

18
Q

reuptake inhibitors for behavioural disorders (4)

A

atomoxetine (NA) (non stimulant)
modafinil (H/NA) - enhances cognition when sleep deprived
methylphenidate - stimulant with calming effect
amphetamine salts

19
Q

reuptake inhibitors for addiction (2)

A

bupoprion, atomoxetine for smoking cessation

20
Q

action of ritalin/atomoxetine

A

preferentially restore level of catecholamines, improve impulse control

alpha2a adrenoceptor agonist - NA enhances signals
D1 receptors - decreases noise

21
Q

cause of ADHD

A

cortical hypofunction
dec subcortical dopamine
reduced impulse control in frontal cortex and striatal region

leads to subcortical vs cortical imbalance

22
Q

MDMA

A

inc 5HT

23
Q

cocaine blockade/amphetamine competition

A

inc DA/inc NA and DA

24
Q

impulse control

A

atomoxetine

amphetamine

25
Q

obesity - sympathomimetic 5HT reuptake inhibitors

A

phentermine/fenfluramine

26
Q

obesity - NA/5HT reuptake inhibitor

A

sibutramine

27
Q

obesity - CB1 blocker

A

rimonabant

28
Q

obesity - 5HT2C blocker

A

lorcaserrin

29
Q

impairment in…. system makes vulnerable to addiction

A

DA

30
Q

Parkinsons for learning and memory

A

achesterase - naergics

31
Q

parkinsons motor dysfunction

A

antimuscarinics and DAergics

32
Q

monoamine pathways

A

discrete modulation

33
Q

cognitive enhancers action

A

monoamine reuptake inhibitors

Systems 3 - Neuro (14 decks)

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