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Systems 3 - Neuro > Dementia > Flashcards

Dementia Flashcards

1
Q

donezipil, galantamine, rivastigmine

A

cholinesterase inhibitors, inc ACh

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2
Q

cholinesterase inhibitor side effects

A

abdo pain, nausea, diarrhoea

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3
Q

memantine

A

partial NMDA antagonist, reduce excitotoxicity and cut out background noise

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4
Q

PBT-2 against clioquinol

A

stop aggregation

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5
Q

statins

A

ApoE = lipid transport molecule and genetic risk factor - cholesterol metabolism linked to APP

lipid raft partitioning/relieve oxidative stress

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6
Q

Bapineuzumab

A

antibody against Abeta - poor outcome in trials but too late?

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7
Q

Rember/Taurex (failed trial)

A

stop aggregation of tau

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8
Q

paclitaxel

A

Tau can no longer stabilise microtubule - help

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9
Q

lithium

A

inhibit GSK3beta (stop hyperphosphorylation)

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Systems 3 - Neuro (14 decks)

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