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Systems 3 - Neuro > Drug addiction > Flashcards

Drug addiction Flashcards

1
Q

block dopamine reuptake and inc conc in synapse

A

cocaine

amphetamine - (plus inhibition of degradation)

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2
Q

disinhibiton of VTA (dec inhib interneurone activity)

A

opioids and alcohol

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3
Q

Nach receptors on vta da neurones to nuc accumbens excited

stimualte Nach receptors on glutamate neurones

A

nicotine

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4
Q

activate cb1 in vta

A

cannabinoids

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5
Q

disinhibiton of prefrontal cortex, inc glut

NMDA blockage

A

phencyclidine, ketamine (hallucinogens)

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6
Q

potentiate glut release via 5HT2A inhibition

A

lsd and psilcybin

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7
Q

miu opioid receptor action

A 
analgesia
euphoria
resp depression
constipation
diuresis
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8
Q

kappa opioid receptor action

A

analgesia

dysphoria and hallucinations

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9
Q

delta opiod receptor action

A

analgesia
preconvulsant
antidepressant

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10
Q

endogenous cannabinoid

A

anandamide

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11
Q

antipsychotic cannabinoid

A

cannabidiol

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12
Q

psychotic cannabinoid

A

cannabinol (THC) - inc in skunk

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13
Q

CB1 antagonist

A

rimonibant - reduce addictive behaviours, inc suicide risk

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14
Q

ethanol channel action

A 
inc GABA and glyceine mediated inhibition
inhib Ca2+
inhib glutamate ionotropics
inhibit adenosine receptors
activate K+ channels
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15
Q

ethanol enhances the effects of…

A

benzodiazepines

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16
Q

ethanol turns cocaine to…

A

toxic cocaethylene

17
Q

symptomatic control of withdrawal

A

propranolol

18
Q

replacement therapy - opioids

A

methandone, bupenorphine, legal heroin

19
Q

replacement therapy - alpha 2 adrenoceptor agonist

A

clonidine, lofexidine

20
Q

replacement therapy - nicotinic alpha4B2 partial agonist

A

varenicline

21
Q

block response of opioids

A

naltrexone

22
Q

block alpha3B4 nicotinic effects

A

mecamylamine

23
Q

immunisation

A

cocaine and nicotine

24
Q

aversive alcohol therapy

A

disulifram

25
Q

reduce nicotine craving

A

bupropion

26
Q

reduce ethanol craving

A

naltrexone
nalfamere
acamprosate (NMDA antag)

27
Q

topiramate and lamotrigine

A

antiepileptics - alcohol/cocaine

28
Q

baclofen

A

opioid, alcohol, stimulants - reduce craving

29
Q

ibogaine

A

reduce opioid and stimulant craving

Systems 3 - Neuro (14 decks)

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