viral hepatitis Flashcards
causes
drug/alcohol induced
autoimmune
ischaemic
symptoms of acute hepatitis
fever malaise fatigue nausea and vomiting diarrhoea jaundice RUQ pain
Mallory’s hyaline bodies
alcoholic liver disease (acute hepatitis) and chronic active hepatitis
alpha feto protein
heptpcellular carcinoma
hepatitis A
RNA virus faecal-oral spread incubation 2-4 weeks fever, malaise and jaundice confirmed with presence of Hep A IgM
Hep A treatment
typically self-limiting
supportive
avoid alcohol
immunisation
Hepatitis B
DNA virus
BBB- blood, babies, B(sexual intercourse)
Hepatitis B complications
chronic hepatitis
hepatocellular carcinoma
fulminant liver failure
hep B management
antivirals (interferon alfa)
aim: clear Hep B surface antigen > causes cirrhosis
Hep B immunisation
given to children 2,3, and 4 months
Hep C
RNA
Hep C transmission
sexual intercourse
IVDU
Hep C symptoms
fatigue
85%- silent chronic infection
25%- cirrhosis > hepatocellular carcinoma
chronic hepatitis
Hep C investigations
anti-HCV= exposure
HCV-PCR test
liver biopsy