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GI/Liver: Pharmacology > Viral Hepatitis 2 > Flashcards

Viral Hepatitis 2 Flashcards

1
Q

Which anti-HBV drugs are L-Nucleosides?

A

Lamivudine

Telbivudine

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2
Q

Which anti-HBV drugs are Acyclic phosphonates?

A

Adefovir

Tenofovir disoproxil fumarate

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3
Q

What anti-HBV drug is a d-cyclopentane?

A

Entecavir

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4
Q

What cross resistance is seen with L1810M and M204V/1 resistance do Lamivudine?

A

Telbivudine

Entecavir

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5
Q

What cross resistance is seen with adefovir resistant N236T?

A

Tenofovir

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6
Q

What cross-resistance is seen with adefovir resistant A181T/V?

A

Lamivudine
Telbivudine
Tenofovir

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7
Q

What Cross resistance is seen with entecavir resistance?

A

Lamivudine

Telbivudine

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8
Q

What is the MOA for Tenofovir disoproxil?

A

pro-drug for tenofovir which is a nucleoside analog of adenosine monophosphate

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9
Q

What is the MOA of entecavir?

A

Guanosine nucleotide analog

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10
Q

What is the MOA of Telbivudine?

A

L-isomer of thymidine

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11
Q

What is the MOA of Adefovir?

A

adenosine monophosphate

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12
Q

What is the MOA of Lamivudine and emtricitabine?

A

L-isomers of cytosine

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13
Q

What are the relative half lives of the anti-HBV drugs?

A

Entecavir (130hr) > Telbivudine (45hr) > Tenofovir (17hr) > Emtricitabine (10hr) > Adefovir (8hr) > Lamivudine (7hr)

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14
Q

Which anti-HBV drugs are excreted unchanged in the urine?

A 
Tenofovir
Entecavir
lamivudine
Emtricitabine
Adeforvir
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15
Q

Which anti-HBV drug is eliminated by a passive process?

A

Telbivudine is excreted in the urine by a passive process.

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16
Q

Which anti-hepatitis drugs should be taken with meals?

A

Tenofovir (take with high fat meal)

17
Q

Which anti-HBV drug should NOT be taken with food?

A

Entecavir

18
Q

What are some important adverse effects associated with Tenofovir?

A

Acute renal failure (rare)

Osteoporosis (give Ca and vit D supplements)

19
Q

Which anti-HBV nucleotide/side analogs caused hepatic toxicity?

A

adefovir
Telbivudine
Entecavir

20
Q

Which anti-HBV nucleotide analogs are effective against both HIV and HBV?

A

Tenofovir
Entecavir (weakly against HIV)
Emtricitabine (off label for HBV, approved for HIV)

GI/Liver: Pharmacology (19 decks)

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