Viral Hepatitis 2 Flashcards
Which anti-HBV drugs are L-Nucleosides?
Lamivudine
Telbivudine
Which anti-HBV drugs are Acyclic phosphonates?
Adefovir
Tenofovir disoproxil fumarate
What anti-HBV drug is a d-cyclopentane?
Entecavir
What cross resistance is seen with L1810M and M204V/1 resistance do Lamivudine?
Telbivudine
Entecavir
What cross resistance is seen with adefovir resistant N236T?
Tenofovir
What cross-resistance is seen with adefovir resistant A181T/V?
Lamivudine
Telbivudine
Tenofovir
What Cross resistance is seen with entecavir resistance?
Lamivudine
Telbivudine
What is the MOA for Tenofovir disoproxil?
pro-drug for tenofovir which is a nucleoside analog of adenosine monophosphate
What is the MOA of entecavir?
Guanosine nucleotide analog
What is the MOA of Telbivudine?
L-isomer of thymidine
What is the MOA of Adefovir?
adenosine monophosphate
What is the MOA of Lamivudine and emtricitabine?
L-isomers of cytosine
What are the relative half lives of the anti-HBV drugs?
Entecavir (130hr) > Telbivudine (45hr) > Tenofovir (17hr) > Emtricitabine (10hr) > Adefovir (8hr) > Lamivudine (7hr)
Which anti-HBV drugs are excreted unchanged in the urine?
Tenofovir Entecavir lamivudine Emtricitabine Adeforvir
Which anti-HBV drug is eliminated by a passive process?
Telbivudine is excreted in the urine by a passive process.
Which anti-hepatitis drugs should be taken with meals?
Tenofovir (take with high fat meal)
Which anti-HBV drug should NOT be taken with food?
Entecavir
What are some important adverse effects associated with Tenofovir?
Acute renal failure (rare)
Osteoporosis (give Ca and vit D supplements)
Which anti-HBV nucleotide/side analogs caused hepatic toxicity?
adefovir
Telbivudine
Entecavir
Which anti-HBV nucleotide analogs are effective against both HIV and HBV?
Tenofovir
Entecavir (weakly against HIV)
Emtricitabine (off label for HBV, approved for HIV)
