HCV treatments

Question 1

How to treat genotype 1 HCV?

Answer 1

BRIT: Boceprevir, Ribavarin, IFN2b (peg), Telaprevir

Question 2

How to treat genotype 2 HCV?

Answer 2

IR: IFN2b (peg), Ribavirin

Question 3

Ribavirin MOA?

Answer 3

1. Increase immune clearance
2. Inh IMPDH (decrease GTP)
3. Inh HCV RdRp (RNA dependent RNA pol)
4. Mutates RNA

Question 4

Do you want to take Ribavirin with high fat or low fat meal?

Answer 4

High fat.. Think eat ribs with Ribavirin

Question 5

Metabolism of Ribavirin?

Answer 5

No CYPs

Question 6

AEs of Ribavirin?

Answer 6

Hemolytic anemia!!
MI!! & Difficulty breating!!
**This is a big deal, test question probably!
Also, Ribavirin is a male teratogen

Question 7

Telaprevir & Boceprevir MOA?

Answer 7

Inh NS3/4A serine protease (a cleavage protein that HCV uses to basically activate itself)

Question 8

Do you want to take Telaprevir & Boceprevir with food?

Answer 8

YES! (Especially Telaprevir, take it with high fat meal) Memory aid: HCV tx is a good excuse to eat high fat meals

Question 9

How are Telaprevir & Boceprevir metabolized?

Answer 9

CYPs (unlike Ribaivrin.. *Dont give a rip about no CYPs)

Question 10

AEs of Telaprevir & Boceprevir?… remember this

Answer 10

Telaprevir = bad rash!