Interferon HBV treatments

Question 1

What 3 things do interferons do?

Answer 1

1. Antiviral
2. Anti-proliferative
3. Immune modulatory

Question 2

Biochem pathway of how interferon works?

Answer 2

Agonizes IFN receptor –> Jak/Stat –> increase enzymes

Question 3

What enzymes does IFN increase?

Answer 3

1. Adenosine deaminase
2. PKR
3. 2,5-oligoadenylate synthase

Question 4

What is 2,5-oligoadenylate synthase?

Answer 4

An endoribonuclease that cleaves viral RNA, inh dsRNA, inh viral penetration, uncoating, assembly, or release, increase cytotoxic T-lymphocyte function

Question 5

What type of IFN treats HBV?

Answer 5

INF2a

Question 6

AEs of IFN?

Answer 6

1. FLS
2. Neuropsych (depression, seizures)
3. Transient thyroid disturbance (Hashimoto or Graves)