GI Tumor treatment: MOAs Flashcards
What is the MOA of brevacizumab?
MAb against VEGF
What is the MOA of Capcitabine?
Oral prodrug to 5-FU
What is the MOA of Cetuximab?
MAb against EGFR
What is the MOA of Cisplatin?
Forms DNA interstrand crosslinks and adducts
What is the MOA of Docetaxel?
Microtubule stabilizer. Inhibits depolymerization
What is the MOA of Doxorubicin?
Intercalator
free radical generator
Topo II inhibitor
What is the MOA of Erlotinib?
EGFR TKI
What is the MOA of flourouracil?
pyrimidine antimetabolite that inhibits thymidylate synthase and interferes with RNA synthesis. Has some effects on DNA.
What is the MOA of Gemcitabine?
DNA polymerase inhibitor via incorporation of triphosphate form during DNA synthesis
What is the MOA of Glutamic acid?
Nutritional supplement that is used to counterbalance deficiencies of HCl in gastric juice.
Its the juice that boosts your juice!!
What is the MOA of Imatinib mesylate?
Oral TKI used in Kit (CD117) positive GIST.
inhibits Bcr-Abl.
What is the MOA of IFN-alpha?
Enzyme activation following cell surface receptor binding and TK activation.
What is the MOA of Irinotecan?
Topo I inhibitor
What is the MOA of Leucovorin?
Reduced folate,
modulate effects of 5-FU
What is the MOA of methysergide?
Serotonin inhibitor of GI tract
What is the MOA of mitomycin?
Mono- or bifunctional alkylating agent
What is the MOA of Octreotide?
Somatostatin analog inhibits hormones/secretions/blood flow in GI tract.
What is the MOA of Oxaplatin?
alkylator like cisplatin but more potent and lacks cross resistance.
What is the MOA of Sorafenib?
Multi kinase TKI (targets Ser/Thr RAF kinase VEGFR-2, VEGFR-3 PDGFR-beta KIT FLT-3 RET
What is the MOA of Sunitinib?
Multi kinase TKI PDGFR alpha/beta VEGFR 1,2, and 3 KIT FLT-3 CSR-1R RET
What is the MOA of Trastuzumab?
HER2/neu antibody
p27 accumulates–> cell cycle arrest
