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GI/Liver: Pharmacology > GI Tumor treatment: MOAs > Flashcards

GI Tumor treatment: MOAs Flashcards

1
Q

What is the MOA of brevacizumab?

A

MAb against VEGF

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2
Q

What is the MOA of Capcitabine?

A

Oral prodrug to 5-FU

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3
Q

What is the MOA of Cetuximab?

A

MAb against EGFR

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4
Q

What is the MOA of Cisplatin?

A

Forms DNA interstrand crosslinks and adducts

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5
Q

What is the MOA of Docetaxel?

A

Microtubule stabilizer. Inhibits depolymerization

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6
Q

What is the MOA of Doxorubicin?

A

Intercalator
free radical generator
Topo II inhibitor

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7
Q

What is the MOA of Erlotinib?

A

EGFR TKI

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8
Q

What is the MOA of flourouracil?

A

pyrimidine antimetabolite that inhibits thymidylate synthase and interferes with RNA synthesis. Has some effects on DNA.

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9
Q

What is the MOA of Gemcitabine?

A

DNA polymerase inhibitor via incorporation of triphosphate form during DNA synthesis

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10
Q

What is the MOA of Glutamic acid?

A

Nutritional supplement that is used to counterbalance deficiencies of HCl in gastric juice.

Its the juice that boosts your juice!!

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11
Q

What is the MOA of Imatinib mesylate?

A

Oral TKI used in Kit (CD117) positive GIST.

inhibits Bcr-Abl.

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12
Q

What is the MOA of IFN-alpha?

A

Enzyme activation following cell surface receptor binding and TK activation.

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13
Q

What is the MOA of Irinotecan?

A

Topo I inhibitor

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14
Q

What is the MOA of Leucovorin?

A

Reduced folate,

modulate effects of 5-FU

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15
Q

What is the MOA of methysergide?

A

Serotonin inhibitor of GI tract

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16
Q

What is the MOA of mitomycin?

A

Mono- or bifunctional alkylating agent

17
Q

What is the MOA of Octreotide?

A

Somatostatin analog inhibits hormones/secretions/blood flow in GI tract.

18
Q

What is the MOA of Oxaplatin?

A

alkylator like cisplatin but more potent and lacks cross resistance.

19
Q

What is the MOA of Sorafenib?

A 
Multi kinase TKI (targets Ser/Thr
RAF kinase
VEGFR-2, VEGFR-3
PDGFR-beta
KIT
FLT-3
RET
20
Q

What is the MOA of Sunitinib?

A 
Multi kinase TKI
PDGFR alpha/beta
VEGFR 1,2, and 3
KIT
FLT-3
CSR-1R
RET
21
Q

What is the MOA of Trastuzumab?

A

HER2/neu antibody

p27 accumulates–> cell cycle arrest

GI/Liver: Pharmacology (19 decks)

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