GI tumor treatment: Adverse effects Flashcards
This just includes the bolded AEs
What are the adverse effects associated with brevacizumab?
Bleeding
GI perforation
Wound dihiscence
What are the adverse effects associated with Capecitabine?
Dihydropyrimidine dehydrogenase deficiency prevents metabolic activation
Contraindicated in renal dysfunction
Adverse CV events (interacts with coumarin)
Neuro toxicity
Hematotoxicity
What are the adverse effects associated with Cetuximab?
Cardiac arrest
respiratory arrest
sudden death
Acneiform rash
What are the adverse effects associated with Cisplatin?
Nephrotoxicity
Myelosuppression
Ototoxicity
Platinum hypersensitivity
What are the adverse effects associated with Docetaxel?
Increased treatment related mortality in NSCLC
Edema
Contraindicated in hepatic disease
Neutropenia (dose limiting toxicity)
What are the adverse effects associated with Erlotinib?
GI toxicity (N/V, diarrhea) Prolonged bleeding increased LFTs Ocular toxicity interstitial lung disease
What are the adverse effects associated with flourouracil?
Severe hematotoxicity
DPD deficiency enhances neurotoxicity
What are the adverse effects associated with Gemcitabine?
Infection
Neuropathy
arthralgia
GI toxicity
What are the adverse effects associated with Doxorubicin?
Bone marrow suppression, secondary malignancy
heart dz
Hepatic dz
extravasational necrosis
What are the adverse effects associated with Glutamic acid?
No serious side effects
What are the adverse effects associated with Imatinib?
GI toxicity
CHF
neuro toxicity
Fluid retention/edema
What are the adverse effects associated with IFN-alpha?
Neuro-psychiatric events
Flu-like symptoms
What are the adverse effects associated with Irinotecan?
Bone marrow suppression
diarrhea
What are the adverse effects associated with leucovorin?
Diarrhea
dehydration
What are the adverse effects associated with Methysergide?
Vasoconstrictor of large and small arteries used in migraine therapy
What are the adverse effects associated with Mitomycin?
Bone marrow suppression
HUS
What are the adverse effects associated with Octreotide?
monitor blood glucose
inhibits insulin and glucagon
Dose related diarrhea
What are the adverse effects associated with Oxaliplatin?
Dose limiting neurotoxicity
Thrombocytopenia (with FU and leucovorin)
GI toxicity
stomatitis
What are the adverse effects associated with Sorafenib?
Hand and foot skin rxn in first 6 weeks of treatment
What are the adverse effects associated with Sunitinib?
Thrombocytopenia
QT prolongation
Rare GI perforation
What are the adverse effects associated with Trastuzumab?
LVEF dysfunction and cardiomyopathy Infusion rxn (anaphylaxis, angioedema) Pulmonary toxicity.
