HBV antivirals

Question 1

If there was a mutation in HBV polymerase, what drug could you use?

Answer 1

Adefovir (cuz its the only one that doesnt inhibit HBV polymerase)

Question 2

What are the HBV treatments that are diphosphates & chain terminators?

Answer 2

Tenofovir & Adefovir (Ten & Addy)

Question 3

Elim of all HBV drugs?

Answer 3

Renal, DOSE ADJUST!!!

Question 4

HBV adenosine analogs?

Answer 4

Lamivudine & Adefovir (Lammy & Addy)

Question 5

HBV cytosine analogs?

Answer 5

Tenofovir & Emtricitabine (Ten & Emtri)

Question 6

HBV guanosine analog?

Answer 6

Entacavir (Enta)

Question 7

Which HBV treatment would you give someone who also had HIV?

Answer 7

Ten & Emtri (these are also in common cuz they are both cytosine analogs)

Question 8

What if a patient had HBV, HIV, and osteoporosis.. What do you give them?

Answer 8

Emtricitabine (cuz Tenofovir can cause osteoporosis)

Question 9

What if a patient had HBV, HIV, and was starting to have renal failure due to chronic DM2?

Answer 9

Emtricitabine (cuz Tenofovir has renal toxicity).. All of them are renally eliminated, but he mentioned Tenofovir as specifically being nephrotoxic

Question 10

HBV treatment that is a prodrug?

Answer 10

Lamivudine (Lammy)

Question 11

Which HBV drug do you want to take with a high fat meal?

Answer 11

Tenofovir

Question 12

Which HBV drug to you want to take on an empty stomach?

Answer 12

Entecavir

Question 13

Preferred treatment for HBV?

Answer 13

Tenofovir & Entecavir

Question 14

Which two HBV drugs do you not want to give to someone who has fatty liver due to chronic alcoholism (or any other type of liver failure)?

Answer 14

Adefovir & Entecavir