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GI/Liver: Pharmacology > Anti-diarrheals > Flashcards

Anti-diarrheals Flashcards

1
Q

How do “water absorbers” work?

A

Pull H2O in and produce more solid stools. They are bulk forming agents (group 1 laxatives)

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2
Q

What kind of anti-diarrheal is Bismuth subsalicylate?

A

“Absorber in the lumen”

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3
Q

How does Bismuth subsalicylate work?

A

Absorbs bacteria/virus/toxin. Useful for travelers diarrhea & H. pylori

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4
Q

How do the opiates work?

A
  1. Decrease salivary/gastric/intestinal secretion; GI motility; cramps
  2. Increase: GI muscle tone; sphincter tone
  3. Anti-spasmodic
  4. Leads to increased contact time b/w luminal material & reabsorptive surface
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5
Q

Whats the only opiate on the CDL? MOA?

A

Loperamide (Imodium): agonizes intestinal opiod receptors (enkephalins) & antagonize calmodulin

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6
Q

What other agent besides opiates alters gut motility and can be used to treat diarrhea?

A

Anti-cholinergics. Propantheline & Dicyclomine are on Garrett’s thing but neither are on the CDL

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GI/Liver: Pharmacology (19 decks)

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