GERD Flashcards
1
Q
Non-drug treatment of GERD?
A
- Decrease meal size
- Lose weight
- Bed elevation
- Eat a low fat diet
- Avoid coffee/peppermint
2
Q
What do prokinetic drugs do? (4 things)
A
- Increase gastric motility
- Improve LES tone
- Increase gastric emptying time
- Enhance esophageal clearance
3
Q
Name the prokinetic drugs
A
- Metoclopramide
- Domperidone
- Cisapride
4
Q
Metoclopramide MOA?
A
Blocks D2 receptors and increases 5-HT4 stimulation (direct 5-HT4 agonist) –> increase PNS tone
5
Q
Domperidone MOA?
A
Blocks D2 receptors and increases 5-HT4 stimulation (NOT a direct 5-HT4 agonist like Metoclopramide)
6
Q
AE of Metoclopramide/Domperidone?
A
Tardive dyskinesia = weird muscle spasms of lower face
7
Q
Tegaserod MOA?
A
5-HT4 agonist –> increase PNS tone
8
Q
What do anti-secretory drugs do?
A
They increase gastric pH. No effect on LES tone, esophageal peristalsis, or gastric emptying
