Viral Hepatitis Flashcards
how do viruses attach to host cells
using receptor binding proteins
what encloses the DNA or RNA of a virus
a virus encoded protein coat called a nucleocapsid
and sometimes a host cell membrane derived envelope
symptoms of hepatitis
jaundice
dark urine
clay coloured stool
nausea and vomiting
loss of appetite
fever
abdominal pain
weakness
which form of hepatitis has direct acting drugs
hep C
are viruses with envelopes more or less sensitive to detergents and antibacterial wipes
more
are faecal oral transmitted viruses more or less resistant than perenteral viruses
much more
how are hep A-E transmitted
A and E - fecal oral
B, C and D - parenteral
which hepatitis viruses cause chronic disease
B, C and D - often
A - never
E - only in transplant patients
which hepatitis viruses are oncogenic
A - no
E - potentially
B and C - yes
D - unknown
what age group mostly gets hep a
children and young adults
how quickly does hep A onset
abruptly
commonly with pyrexia
common reason for hep A disease
shellfish eaten raw or uncooked that have growth in contaminated water
what % make a complete recovery from hep A
98%
come age of hep B infection
babies and young adults
transmission modes of hep B
mum-baby (vertical)
sexual
how long does hep B virus last in body
for life
may reactive under immunosuppresion
treatment for chronic hep B infection
interferon alpha or antivirals
treatment for hep a
supportive
where in the world is hep b most prevalent
south east asia
parts of china
sub-saharan african
what % of babies/children infected with hep b go on to have chronic infection and how does this teens/adults
80-95% - children
5-10% - adults
what age gets hep c
adults
what is presentation of acute hep c infection
usually asymptomatic
hep c treatment
interferon alpha and ribavirin
or
direct acting antivirals
what is required for hep D replication
hep B
hep e treatment
supportive
ribavirin for chronic infection
viral causes of hepatitis
hep A-E
non-A/E hepatitis
epstein barr virus
cytomegalovirus
herpes simplex virus
rubella virus
enteroviruses
yellow fever virus
