Vinca Alkaloids--> cycle specific

Question 1

How do vinca alkaloids work?

Answer 1

binds to protein tubulin and disrupts mitotic spindle formation. Prevents cell division in the mitosis phase

Question 2

Common side effects of all vinca alkaloids

Answer 2

myelosuppression

Question 3

Vincristine (Oncovin)

Answer 3

IV

ALL, AML, CML, HD, NHL, MM, small cell lung cancer, rhabdomyosarcoma, neuroblastoma, ewings sarcoma, wilm’s tumor, brain and thyroid cancers

Side effects: M, sensory neuropathy, constipation, SIADH, hypersensitivity reactions, jaw pain

Interactions: sensitive to CYP3A4 inhibitors and inducers. Bowel regimen to prevent constipation

Question 4

Vinblastine (Velban)

Answer 4

IV

breast, testicular, SCC of HN, sarcoma, HD

Side effects: M,mucositis, stomatitis, constipation, HTN, alopecia, jaw pain

Interactions: sensitive to CYP3A4 inhibitors and inducers. Bowel regimen to prevent constipation

Question 5

Vinorelbine (Navelbine)

Answer 5

IV

Breast, ovarian, NSCLC

Side effects: M,N,V,constipation, stomatitis, anorexia, elevations in liver function tests