Antitumor antibiotics- anthracyclines--> cycle specific

Question 1

Common side effects of anthracyclines

Answer 1

Myelosuppression, Nausea, Vomiting, Diarrhea, Mucositis, Cardiotoxicity, alopecia

Question 2

Daunorubicin (Daunomycin)- think blood

Answer 2

IV

ALL, AML

Side effects: common + anorexia, hyperuremia, red urine, hyperpigmentation

Question 3

Doxorubicin (Adriamycin)

Answer 3

IV

Breast, ovarian, prostate, HN, lung, liver, ALL, AML, MM, HD, NHL

Side effects: common + anorexia, hand/foot, hyperpigmentation, red urine, infusion reaction

Question 4

Liposomal Doxorubicin (Doxil)

Answer 4

IV

Karposi’s sarcoma, sarcoma, MM, ovarian, liver

Common + hand/foot, hyperpigmentation, red urine, infusion reaction

Question 5

Epirubicin (ellence)

Answer 5

IV

Breast, gastric

Side effects: Common + skin rash, red urine

Question 6

Idarubicin (Idamycin)

Answer 6

IV

AML, ALL, CML, MDS

Side effects: common + skin rash, elevated liver enzymes, red urine