Antitumor Antibiotics- cycle specific

Question 1

What does an antitumor antibiotic do?

Answer 1

Inhibits cell division by binding to DNA and interfering with RNA synthesis

Question 2

Common side effects of antitumor antibiotics

Answer 2

varried side effects

Question 3

Bleomycin (Blenoxane)

Answer 3

IV, SC, IM

HN, SCC of skin, melanoma, cervix, vulva, testicular, HD, NHL

Side effects: pulmonary tox, renal tox, infusion reaction, skin and nail changes

Question 4

Dactinomycin (Actinomycin-D)- think rareish tumors

Answer 4

IV

Ewing sarcoma, rhabdomyosarcoma wilm’s tumor, testicular

Side effects: M,N,V, mucositis, diarrhea, anorexia, alopecia

Question 5

Mitomycin-C (Mutamycin)- think GI and breast

Answer 5

IV

HN, esophagus, lung, stomach, pancreas, bladder, anus, breast

Side effects: M,N,V, mucositis, diarrhea, anorexia, fatigue, alopecia, Renal tox, pulmonary tox