protein-targeted therapies- proteasome inhibitors

Question 1

What does a proteasome inhibitor do?

Answer 1

inhibits the breakdown of intracellular proteins and disrupt the proteasome pathway

Question 2

Bortezomib (velcade)

Answer 2

IV or SC

Avoid green tea, Sensitive to CYP3A4 inhibitors and inducers

Question 3

example of proteasome inhibitor

Answer 3

bortezomib (velcade)- MM, MCL