Epipodophyllotoxins--> cycle specific

Question 1

How do epipodophyllotoxins work?

Answer 1

Damages cells prior to mitosis, late S and G2 phases. Inhibits topoisomerade II.

Question 2

What are common side effects of epipodophyllotoxins?

Answer 2

Myelosuppression, Nausea, Vomiting

Question 3

Etoposide (Vepesid, VP-16)- Think GI and germ

Answer 3

IV

SCLC, NSCLC, HN, gastric, germ cell, NHL

Side effects: M,N,V, diarrhea, mucositis, anorexia, metallic taste, hypersensitivity reaction, alopecia, orthostatic hypertension

Question 4

Teniposide (vumon, VM-26)

Answer 4

IV

Childhood ALL

M,N,V, hypotension, pulmonary toxicity