protein-targeted therapies- mTOR inhibitors

Question 1

what does an mTOR inhibitor do?

Answer 1

blocks angiogenesis by preventing release of VGEF and PDGF, thus blocking tumor cell proliferation and causing cell death

Question 2

Types of mTOR inhibitors

Answer 2

Temsirolimus (Torisel)

Everolimus (affinitor)

Question 3

Indications for mTOR inhibitors

Answer 3

Temsirolimus (Torisel)- renal

Everolimus (affinitor)- renal, pancreatic neuroendocrine

Question 4

Everolimus (affinitor)

Answer 4

PO

Interactions: take with or without food
Senitive to CYP3A4 inhibitors and inducers. DO not crush or chew drug

Question 5

Temsirolimus (torisel)

Answer 5

IV

Interactions: alters glucose metabolism (hyperglycemia), can cause hypercholesterolemia