Hormone therapies Flashcards
Types of hormone therapies
selective estrogen receptor modulators aromatase inhibitors progesterones antiandrogens leutinizing hormone -releasing hormone antagonists
what does a selective estrogen receptor modulator (SERMS) do?
non-steroidal anti-estrogen agents that compete with estrogen for binding to estrogen receptors
Examples of SERMS
Tamoxifen citrate (Novaldex)- breast Tamoxifene citrate (FFareston)- breast Raloxifene (evista)- treats osteoporosis for postmenopausal women at risk for breast cancer
Tamoxifen (Nolvadex)
PO
take with or without food
interactions: avoid antacids with drug. Sensitive to CYP3A4 inhibitors and inducers
what does an aromatase inhibitor do?
inhibits aromatase. Blocks the production of estrogen by inhibiting the conversion of adrenal androgens to estrogen. Used in postmenopausal women only
examples of aromatase inhibitors
anastrazole (arimidex) - breast
letrozole (femara)- breast
Exemestane (aromasin)- breast
side effects of SERMS
hot flashes/menstrual symptoms, fluid retention, increased risk of endometrial cancer, thromboembolitic complications, skin changes/rash, joint pain, weight gain
side effects of aromatase inhibitors
hot flashes, arthralgias, n,v, asthenia, thromboembolic events, high cholesterol, fever, maliase, myalgias, joint pain
exemestane (aromasin)
PO- take directly after meal
interactions: CYP3A4 inducers decrease activity
what does a progesterone do?
possesses anti-estrogenic effects, inhibits use of estrogen receptors
examples of progesterones
megestrol (megace)- breast, endometrial, renal, and as an appetite stimulant
side effects of progesterones
wt gain, thromboembolic events,n,v, menstrual bleeding, hot flashes, hyperglycemia
what do anti-androgens do?
bind to androgen receptors and block effects of testosterone
examples of anti-androgens
bicalutamide ( casodex)- prostate
flutamide (eulexin)- prostate
side effects of anti-androgens
wt gain, hot flashes, fatigue, decreased libido, impotence, bone pain
