Taxanes--> cycle specific

Question 1

How does a taxane work

Answer 1

active in the mitosis phase of the cell cycle. Anti-microtubule agent, which leads to inhibition of mitosis and cell division

Question 2

Common side effects of all taxanes?

Answer 2

Myelosuppression, mucositis, diarrhea

Question 3

Paclitaxel (Taxol)- think solid tumors

Answer 3

IV

HN, esophageal, SCLC, NSCLC, pancreas, bladder, ovarian, prostate

Side effects: M,Muc,D, sensory neuropathy, hypersensitivity reaction, alopecia, changes in liver labs (transanimases, bilirubin, alk phos), arthralgia, myalgia

Question 4

Protein-bound paclitaxel (Abraxane)

Answer 4

IV

Breast, NSCLC

Side effects: M,Muc,D,N,V, arthralgia, myalgia, alopecia

Question 5

Docetaxel (taxotere)

Answer 5

IV

HN, NSCLC, gastric, breast, ovarian, prostate

Side effects: M,Muc,D, neurotoxicity, fluid retention, skin and nail changes, hypersensitivity reaction, changes in liver labs (transanimases, bilirubin, alk phos)