Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

4 Reviewer A - Veterinary Pharmacology > Veterinary Pharma - Clinical Pharmacology Blood coagulation > Flashcards

Veterinary Pharma - Clinical Pharmacology Blood coagulation Flashcards

1
Q

Term for spontaneous arrest of bleeding from damaged blood vessels

A

Hemostasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Generally, what are the steps in hemostasis? (6)

A

Trauma/Damage to blood vessels
Blood vessel spasm
Platelets stick to the exposed collagen of blood vessels
Platelet plug formation
Fibrin reinforces platelet plug
Formation of blood clot

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the 3 stages of intrinsic fibrin formation?

A

Activation of Factor 10 (Stuart power factor)
Formation of thrombin
Formation of fibrin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

In terms of coagulation factors, what are the factors activated in order?

A

Factor 10
Factor 10a
Factor 2
Factor 1
Factor 2a
Factor 13
Factor 13 a

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Term for a process of removal of formed fibrin.

A

Fibrinolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

The proteolytic enzyme that is responsible for fibrinolysis

A

Plasmin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Generally, what are the steps for fibrinolysis? (5)

A

Cells are injured
Plasminogen is released
Plasminogen is converted to plasmin
Plasmin mediates fibrinolysis
Remodeling of thrombus by plasmin digesting fibrin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the two (2) classes of drugs that affects blood coagulation?

A

Hemostatics
Antihemostatics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Hemostatics are also known as?

A

Procoagulants

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Antihemostatics are also known as?

A

Anticoagulants

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What does hemostatics or procoagulants do?

A

Prevents bleeding

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What does antihemostatics or anticoagulants do?

A

Limit formation of intravascular clot (thrombi)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Under Antihemostatic class drugs, what are the 3 subclasses?

A

Anticoagulants
Fibrinolytics/Thrombolytics
Antithrombotics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the class of antihemostatic drugs that prevents blood coagulation?

A

Anticoagulants

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the class of antihemostatic drugs that increases plasmin activity which in turn dissolves more clots?

A

Fibrinolytics/Thrombolytics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the class of antihemostatic drugs that controls platelet activity?

A

Antithrombotics

17
Q

A serine proteolytic enzyme produced by the endothelial cells or synthetically produced which catalyzes the conversion of plasminogen to plasmin. Used for thromboembolism in cats and dogs.

A

Tissue plasminogen activator

18
Q

What are examples of antihemostatic drugs which are anticoagulants? (2) WH

A

Warfarin
Heparin

19
Q

What are examples of antihemostatic endogenouse substance which are anticoagulants? (2) AP

A

Antithrombin 3
Protein C

20
Q

What does antihemostatics anticoagulant do?

A

Interfere with the role of Vitamin K

21
Q

What does Vitamin K do in procoagulations?

A

Required for carboxylation of clotting factors

22
Q

What clotting factors does Vitamin K affect? (4)

A

Factor 2
Factor 7
Factor 9
Factor 10

23
Q

How does warfarin and heparin affect anticoagulation

A

Vitamin K role interference

24
Q

What are examples of antihemostatic drugs which are fibrinolytics/thrombolytic? (5) SAUAR

A

Streptokinase
Anisteplase
Urokinase
Alteplase
Reteplase

25
Q

Antihemostatic which is fibrinolytic/thrombolytic enzyme synthesized from streptococcal organisms

A

Streptokinase
Streptodornase

26
Q

Antihemostatic which is fibrinolytic/thrombolytic enzyme that is synthesized by culture from human renal cell

A

Urokinase

27
Q

What are examples of antihemostatic drugs which are antiplatelet or antithrombotics? (5) AETCA

A

Abciximab
Eptifibatide
Ticlopidine
Clopidofrel
Aspirin

28
Q

Antidote for heparin-induced hemorrhages

A

Protamine sulfate

29
Q

How does protamine sulfate help with heparin-induced hemorrhages?

A

Antagonist

30
Q

A synthetic analogue which releases preformed Von Willebrand Factor (VWF) from endothelial cells and macrophages

A

Desmopressin

31
Q

What are the two (2) types of local hemostatics?

A

Astringents
Fibrin foam

32
Q

What are examples of local hemostatics? (3)

A

Thromboplastin USP
Thrombin USP - 1
Absorbable gelatin sponge USP

33
Q

What are examples of astringents? (3)

A

Ferric sulfate
Silver nitrate
Tannic acid

34
Q

What are examples of systemic coagulants? (8)

A

Heparin Na
Warfarin
Bishyroxycoumarin
Dicoumarol
Na oxalate
Na citrate
Edetate disodium heparin Na
Acid citrate dextrose solution

35
Q

What do you call substances that are essential to the proper formation of the components of blood?

A

Hematinics

36
Q

What are examples of hematinics?

A

Folic acid
Vitamin B12
Iron
Epoetin alfa
Anabolic steroids
Epinephrine
Norepinehprine
Vitamin K
Desmopressin

4 Reviewer A - Veterinary Pharmacology (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions