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4 Reviewer A - Veterinary Pharmacology > Veterinary Pharma - Clinical Pharmacology NSAIDs > Flashcards

Veterinary Pharma - Clinical Pharmacology NSAIDs Flashcards

1
Q

What are the important drug groups for veterinary clinical pharmacology? (9) NGACDBRDC

A

Non-steroidal anti-inflammatory drugs
Glucocorticoids
Autacoids
Cardiovascular drugs
Diuretics
Drugs affecting blood coagulation
Drugs affecting respiratory system
Drugs affecting digestive system
Chemotherapy

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2
Q

What are the drugs under the NSAID group (14) ASMNIKMAFIPDOP

A

Aspirin/acetylsalicylic acid
Sodium salicylate
Methylsalicylic acid
Naproxen
Ibuprofen
Ketoprofen
Meclofenamic acid
Acetaminophen/paracetamol
Flunixin meglumine
Indomethacin
Phenylbutazone
Oxyphenbutazone
Piroxicam

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3
Q

What are the general properties of NSAID drugs?

A

Weak acid
Binds well with protein
Accumulates in stomach, kidneys and small intestine
Inhibits enzymes (COX-1 and COX-2) that form prostaglandin
Reduce pain in inflamed tissue/s
Reduce fever

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4
Q

A unique NSAID drug that is recently introduced which inhibits Lipoxygenase

A

Tepoxalin

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5
Q

Of the two isoforms of cyclooxygenase (COX), which one is present in all tissues, and catalyzes formation of prostaglandin?

A

COX -1

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6
Q

What physiological effects does prostaglandin usually do that NSAIDs mediate? (3)

A

Hemostasis
Gastrointestinal mucosal protection
Kidney protection from hypotensive insult

These are all the physiological response that drugs affecting COX - 1 mediate when taken

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7
Q

Of the two isoforms of cyclooxygenase (COX), which one is activated only in damaged and inflamed tissues, and catalyzes formation of prostaglandin and prostaglandin E2?

A

COX - 2

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8
Q

What physiological effect happens when the prostaglandin and prostaglandin E2 (dinoprostone) production is mediated?

A

Intensification inflammatory response

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9
Q

What physiological effects does the prostaglandin E2 do?

A

Thermoregulation
Pain response to injury

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10
Q

This action of NSAIDs is the one responsible for antipyretic, analgesic, and anti-inflammatory response.

A

COX - 2 inhibition

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11
Q

This action of NSAIDs is responsible for unwanted gastric ulceration and renal toxicity

A

COX - 1 inhibition

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12
Q

What NSAID drugs produce favorable ratios of COX - 1 and COX -2 inhibition in dogs? (3) CMD

A

Caprofen
Meloxicam
Deracoxib

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13
Q

What NSAID drugs produce unfavorable ratios of COX - 1 and COX -2 inhibition in dogs? (3) APP

A

Aspirin
Phenylbutazone
Piroxicam

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14
Q

NSAID drugs that are considered chondrotoxic because they they inhibit synthesis of cartilage proteoglycans. (3) ANI

A

Aspirin
Naproxen
Ibuprofen

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15
Q

NSAID drugs that are considered Chondroneutral, meaning they may they inhibit synthesis of cartilage proteoglycans, depending their dose. (2) CM

A

Caprofen
Meloxicam

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16
Q

NSAID drug that has been shown to reduce tumor size such in transitional cell carcinoma in dogs.

A

Piroxicam

17
Q

Food can impair oral absorption of NSAID drugs in these animals (2)

A

Horses
Ruminants

18
Q

Does NSAID drugs undergo enterohepatic circulation: Yes or no?

A

Yes

Some, specifically Naproxen, etodolac, and meclofenamic acid

19
Q

Based on structure, most NSAID can be divided into these two (2) groups/derivatives

A

Carboxylic acid
Enolic acid

20
Q

What are the subdivisions of Enolic acid NSAIDs? (2)

A

Pyrazolones
Oxicams

21
Q

Enolic acid NSAID are subdivided into pyrazolones and oxicams. What NSAIDs are under pyrazolones? (3) POR

A

Phenylbutazone
Oxyphenbutazone
Ramifenazone

22
Q

Enolic acid NSAID are also called pyrazolones and oxicams. What NSAIDs are under oxicams? (3) MPT

A

Meloxicam
Piroxicam
Tenoxicam

23
Q

What are the subdivisions of Carboxylic acid NSAIDs? (6) SPAPAI

A

Salicylates
Proprionic acids
Anthranilic acids
Phenylacetic acids
Aminonicotinic acids
Indolines

24
Q

Carboxylic acid NSAID are subdivided into 6 subgroups. What NSAID drug is under Salicylates?

A

Aspirin

25
Q

Carboxylic acid NSAID are subdivided into 6 subgroups. What NSAID drugs is under Propionic acid?

A

Ibuprofen
Naproxen
Caprofen
Ketoprofen
Vedaprofen

26
Q

Carboxylic acid NSAID are subdivided into 6 subgroups. What NSAID drugs is under Anthranilic acid?

A

Tolfenamic acid
Meclofenamic acid

27
Q

Carboxylic acid NSAID are subdivided into 6 subgroups. What NSAID drug is under Phenylacetic acid?

A

Acetaminophen

28
Q

Carboxylic acid NSAID are subdivided into 6 subgroups. What NSAID drug is under Aminonicotinic acid?

A

Flunixin meglumine

29
Q

Carboxylic acid NSAID are subdivided into 6 subgroups. What NSAID drug is under Indolines?

A

Indomethacin

30
Q

Generally, what are the clinical use of NSAID drugs? (3)

A

(1)Analgesic
(2)Treatment of acute inflammation of musckuloskeletal system
(3)Treatment of non-immune inflammation of musckuloskeletal system

31
Q

Specifically, what are the clinical uses of NSAID drugs?(4)

A

(1)Treament for equine colic
(2)Adjunct treatment for GIT infection
(3)Treatment of acute respiratory disease of calves and pigs
(4)Treatment of anaphylactic reactions in cattles

32
Q

Drug:
Animal:route -
Indication:
Contraindication:

A

4 Reviewer A - Veterinary Pharmacology (15 decks)

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