Clinical Pharmacology Flashcards
What are the 5 actions of antibacterial drugs?
Inhibition of cell wall synthesis
Impairment of cell membrane
Inhibition of protein synthesis
Inhibition of Nucleic acid
Inhibition of Folate cofactors synthesis
Examples of antibiotic that inhibit cell wall synthesis (5)
PCBVC
Penicillin
Cephalosporin
Bacitranin
Vancomycin
Cycloserine
Examples of antibiotics that impairs the bacterial cell membrane (5) PCTGA
Polymyxin B
Colistin
Tyrothricin
Gramicidin
Amphotericine B
Examples of antibiotics that inhibits protein synthesis (7) ASTMLTV
Aminoglycosides
Spectinomycin
Tetracycline
Macrolides
Lincosamides
Tiamulin
Virginiamycin
Antibiotics classified under Aminoglycosides
(6) SDNGKA
Streptomycin
Dihydrostreptomycin
Neomycin
Gentamicin
Kanamycin
Apramycin
Antibiotics under macrolides (5)
TESOC
Tylosin
Erythromycin
Spiramycin
Oleandomycin
Clarithromycin
Antibiotics under Lincosamides (2)
Lincomycin
Clindamycin
Examples of antibiotics that inhibits Nucleic acid (4) QNRN
Quinolones
Novobicin
Rifamycin
Nitrofurans
Antibiotics under Quinolones (3) EON
Enrofloxacin
Oxalinic acid
Nalidixic acid
Antibiotics under Nitrofurans (3) NFF
Nitrofurazone
Furazolidone
Furaltadone
Examples of antibiotics that inhibit Folate cofactor synthesis (3) SStT
Sulfonamides
Sulfonamide-Trimethoprim
Trimethoprim
What do you call penicillin from non penicillinase producing bacteria ?
Natural penicillins
Examples of natural penicillins (2)
Penicillin G
Penicillin V
Describe the action of Pen G (3)
Long acting
✓ Gram - bacteria
✓ UTI
Describe action of Pen V
✓ Gram + infections
What are the categories of Penicillins? (3)
Natural Penicillins
Penicillinase - stable penicillins / Anti staph
Broad spectrum
Example of Penicillinase- stable penicillin Antistaph (6) CODMNQ
Cloxapenicillin
Oxapenicillin
Dicoxapenicillin
Methipenicillin
Natpenicillin
Quinapenicillin
False substrates for penicillinase which protects penicillin antibiotics. Usually combined with Amoxicillin. CST
Clavulanic acid
Sulbactam
Tazobactam
Penicillin antibiotics that are used to treat Gram - aerobes. ✓ E. coli, Haemoproteus, proteus. × Klebsiella, Pseudomonas (AAH)
Amoxicillin
Ampicillin
Hetacillin
Penicillin antibiotics which are antipseudomonal. Usually combined with tobramycin or gentamycin. Aka. Carboxypenicillins (CIT)
Carbenicillin
Indanyl carbenicillin
Ticarcillin
Penicillin antibiotics that works on Klebsiella, Enterobacter, Pseudomonas (3) PAM
Piperacillin
Azlocillin
Mezlocillin
Acid-labile penicillin antibiotics
PMT
Penicillin G
Methicillin
Ticarcillin
During inflammation, penicillin can cross _ , which it normally cannot? (3)
Blood brain barrier
Placenta
Mammany barriers
