Clinical Pharmacology

Question 1

What are the 5 actions of antibacterial drugs?

Answer 1

Inhibition of cell wall synthesis
Impairment of cell membrane
Inhibition of protein synthesis
Inhibition of Nucleic acid
Inhibition of Folate cofactors synthesis

Question 2

Examples of antibiotic that inhibit cell wall synthesis (5)
PCBVC

Answer 2

Penicillin
Cephalosporin
Bacitranin
Vancomycin
Cycloserine

Question 3

Examples of antibiotics that impairs the bacterial cell membrane (5) PCTGA

Answer 3

Polymyxin B
Colistin
Tyrothricin
Gramicidin
Amphotericine B

Question 4

Examples of antibiotics that inhibits protein synthesis (7) ASTMLTV

Answer 4

Aminoglycosides
Spectinomycin
Tetracycline
Macrolides
Lincosamides
Tiamulin
Virginiamycin

Question 5

Antibiotics classified under Aminoglycosides
(6) SDNGKA

Answer 5

Streptomycin
Dihydrostreptomycin
Neomycin
Gentamicin
Kanamycin
Apramycin

Question 6

Antibiotics under macrolides (5)
TESOC

Answer 6

Tylosin
Erythromycin
Spiramycin
Oleandomycin
Clarithromycin

Question 7

Antibiotics under Lincosamides (2)

Answer 7

Lincomycin
Clindamycin

Question 8

Examples of antibiotics that inhibits Nucleic acid (4) QNRN

Answer 8

Quinolones
Novobicin
Rifamycin
Nitrofurans

Question 9

Antibiotics under Quinolones (3) EON

Answer 9

Enrofloxacin
Oxalinic acid
Nalidixic acid

Question 10

Antibiotics under Nitrofurans (3) NFF

Answer 10

Nitrofurazone
Furazolidone
Furaltadone

Question 11

Examples of antibiotics that inhibit Folate cofactor synthesis (3) SStT

Answer 11

Sulfonamides
Sulfonamide-Trimethoprim
Trimethoprim

Question 12

What do you call penicillin from non penicillinase producing bacteria ?

Answer 12

Natural penicillins

Question 13

Examples of natural penicillins (2)

Answer 13

Penicillin G
Penicillin V

Question 14

Describe the action of Pen G (3)

Answer 14

Long acting
✓ Gram - bacteria
✓ UTI

Question 15

Describe action of Pen V

Answer 15

✓ Gram + infections

Question 16

What are the categories of Penicillins? (3)

Answer 16

Natural Penicillins
Penicillinase - stable penicillins / Anti staph
Broad spectrum

Question 17

Example of Penicillinase- stable penicillin Antistaph (6) CODMNQ

Answer 17

Cloxapenicillin
Oxapenicillin
Dicoxapenicillin
Methipenicillin
Natpenicillin
Quinapenicillin

Question 18

False substrates for penicillinase which protects penicillin antibiotics. Usually combined with Amoxicillin. CST

Answer 18

Clavulanic acid
Sulbactam
Tazobactam

Question 19

Penicillin antibiotics that are used to treat Gram - aerobes. ✓ E. coli, Haemoproteus, proteus. × Klebsiella, Pseudomonas (AAH)

Answer 19

Amoxicillin
Ampicillin
Hetacillin

Question 20

Penicillin antibiotics which are antipseudomonal. Usually combined with tobramycin or gentamycin. Aka. Carboxypenicillins (CIT)

Answer 20

Carbenicillin
Indanyl carbenicillin
Ticarcillin

Question 21

Penicillin antibiotics that works on Klebsiella, Enterobacter, Pseudomonas (3) PAM

Answer 21

Piperacillin
Azlocillin
Mezlocillin

Question 22

Acid-labile penicillin antibiotics
PMT

Answer 22

Penicillin G
Methicillin
Ticarcillin

Question 23

During inflammation, penicillin can cross _ , which it normally cannot? (3)

Answer 23

Blood brain barrier
Placenta
Mammany barriers